Phenotypes associated with this allele

• Allele Symbol: Chrna2^tm1.1Slot
• Allele Name: targeted mutation 1.1, Shahrdad Lotfipour
• Allele ID: MGI:7621414
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Chrna2^tm1.1Slot/Chrna2^tm1.1Slot	involves: 129S4/SvJae * 129S4/SvJaeSor * C57BL/6J	MGI:7621646

Genotype
MGI:7621646

hm1

• Allelic Composition: Chrna2^tm1.1Slot/Chrna2^tm1.1Slot
• Genetic Background: involves: 129S4/SvJae * 129S4/SvJaeSor * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:272596 )

♂N • normal stereotypical behavior in contextual fear conditioning chamber on preexposure day 1 when treated with either saline or nicotine

♂N • normal rearing behavior in contextual fear conditioning chamber on preexposure day 1 when treated with nicotine

♂N • normal behavior in open field test when treated with either saline or nicotine

♂N • normal time spent in center and perimeter in contextual fear conditioning chamber on preexposure day 1 when treated with either saline or nicotine

impaired contextual conditioning behavior ( J:272596 )

♂ • no enhanced freezing behavior on test day 3 after preexposure on day 1 when treated with saline

♂ • normal (enhanced) freezing behavior on test day 3 after preexposure on day 1 when treated with nicotine

♂ • normal (enhanced) freezing behavior on test day 2 after preexposure on day 1 when treated with either saline or nicotine

increased vertical activity ( J:272596 )

♂ • increased rearing behavior in contextual fear conditioning chamber on preexposure day 1 when treated with saline

♂ • normal rearing behavior in contextual fear conditioning chamber on preexposure day 1 when treated with nicotine

increased locomotor activity ( J:272596 )

♂ • increased mid-line crossing in contextual fear conditioning chamber on preexposure day 1 when treated with either saline or nicotine

♂ • increased locomotor activity in contextual fear conditioning chamber on preexposure day 1 when treated with either saline or nicotine

♂ • increased shock reactivity on test day 2 after preexposure on day 1 when treated with either saline or nicotine

nervous system

nervous system phenotype ( J:272596 )

♂N • normal stimulusresponse relationships in Schaffer collateral (SC) pathway

enhanced long-term potentiation ( J:272596 )

♂ • 100x more sensitive response of oriens lacunosum moleculare (OLM) GABAergic interneurons to nicotine-induced LTP

growth/size/body

growth/size/body region phenotype ( J:272596 )

♂N • normal postnatal weight gain

♂N • no obvious morphological changes

embryo

embryo phenotype ( J:272596 )

♂N • mice born at expected Mendelian and sex ratios