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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Gnb1em1Dgold
endonuclease-mediated mutation 1, David B Goldstein
MGI:7620469
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Gnb1em1Dgold/Gnb1em1Dgold C57BL/6NJ-Gnb1em1Dgold MGI:7621196
ht2
Gnb1em1Dgold/Gnb1+ C57BL/6NJ-Gnb1em1Dgold MGI:7621197
ht3
Gnb1em1Dgold/Gnb1+ involves: 129P2/OlaHsd * C57BL/6NJ * FVB MGI:7621199


Genotype
MGI:7621196
hm1
Allelic
Composition
Gnb1em1Dgold/Gnb1em1Dgold
Genetic
Background
C57BL/6NJ-Gnb1em1Dgold
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gnb1em1Dgold mutation (0 available); any Gnb1 mutation (61 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging




Genotype
MGI:7621197
ht2
Allelic
Composition
Gnb1em1Dgold/Gnb1+
Genetic
Background
C57BL/6NJ-Gnb1em1Dgold
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gnb1em1Dgold mutation (0 available); any Gnb1 mutation (61 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• between ages P0 and 6 weeks
• between ages P0-P6

behavior/neurological
N
• normal grip strength between ages P4-P10
• normal rearing behavior and time spent in center in open field test
• normal behavior in rotarod test
• normal behavior in contextual and cued fear conditioning tests
• normal swimming speed in Morris water maze test
• longer acquisition latency to platform in Morris water maze test
• longer reversal latency to platform in Morris water maze test
• faster at age P4 but slower at age P8-P10
• longer latency to turn 90 or 180 degrees from downward-facing start position on a slope between ages P4-P10
• shorter distance traveled in open field test
• lower than expected Mendelian ratio at age P0 owing to deficient maternal behavior
• fewer separation-induced ultrasonic vocalizations (USVs) between ages P5-P9
• significantly lower electroconvulsive threshold (ECT)
• highly frequent generalized bilateral spike-and- wave discharges (SWDs)

nervous system
• significantly lower electroconvulsive threshold (ECT)
• highly frequent generalized bilateral spike-and- wave discharges (SWDs)




Genotype
MGI:7621199
ht3
Allelic
Composition
Gnb1em1Dgold/Gnb1+
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6NJ * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gnb1em1Dgold mutation (0 available); any Gnb1 mutation (61 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
N
• normal grip strength between ages P4-P10
• faster at age P4 but slower at ages P8-P10
• longer latency to turn 90 or 180 degrees from downward-facing start position on a slope between ages P4-P10
• fewer separation-induced ultrasonic vocalizations (USVs) between ages P4-P8
• highly frequent generalized bilateral spike-and- wave discharges (SWDs)

nervous system
• highly frequent generalized bilateral spike-and- wave discharges (SWDs)

growth/size/body
• between ages P0 and 6 weeks
• between ages P4-P6

embryo
N
• mice born at expected Mendelian ratio





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
05/28/2024
MGI 6.13
The Jackson Laboratory