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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ms4a6dem2Ywch
endonuclease-mediated mutation 2, Yongwen Chen
MGI:7618318
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ms4a6dem2Ywch/Ms4a6dem2Ywch C57BL/6-Ms4a6dem2Ywch MGI:7618348


Genotype
MGI:7618348
hm1
Allelic
Composition		 Ms4a6dem2Ywch/Ms4a6dem2Ywch
Genetic
Background		 C57BL/6-Ms4a6dem2Ywch
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ms4a6dem2Ywch mutation (0 available); any Ms4a6d mutation (28 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased susceptibility to endotoxin shock ( J:342776 )
• mice show higher survival rates than wild-type mice following LPS-mediated induction of endotoxin lethality
• LPS-treated mice exhibit higher body temperatures and lower composite clinical scores and lower expression of TNF-alpha and proIL-1beta in peritoneal macrophages leading to lower levels of serum IL-1beta and IL-6 accumulation




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/21/2024
MGI 6.23 		The Jackson Laboratory