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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Mbtps2em2Sapo
endonuclease-mediated mutation 2, Sandra Pohl
MGI:7614893
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Mbtps2em2Sapo/Mbtps2em2Sapo involves: C57BL/6J * CBA MGI:7615089
ht2
 		Mbtps2em2Sapo/Mbtps2+ involves: C57BL/6J * CBA MGI:7615087
ot3
 		Mbtps2em2Sapo/Y involves: C57BL/6J * CBA MGI:7615088


Genotype
MGI:7615089
hm1
Allelic
Composition		 Mbtps2em2Sapo/Mbtps2em2Sapo
Genetic
Background		 involves: C57BL/6J * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mbtps2em2Sapo mutation (0 available); any Mbtps2 mutation (13 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging




Genotype
MGI:7615087
ht2
Allelic
Composition		 Mbtps2em2Sapo/Mbtps2+
Genetic
Background		 involves: C57BL/6J * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mbtps2em2Sapo mutation (0 available); any Mbtps2 mutation (13 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
skeleton phenotype ( J:344727 )
N
• normal growth plate length
• normal subchondral and trabecular bone mineralization in tibia at age 6 weeks
decreased long bone epiphyseal plate size ( J:344727 )
• thinner subchondral bone plate in tibia at age 6 weeks
abnormal osteocyte canaliculus morphology ( J:344727 )
• fewer and shorter canaliculi in tibia at age 6 weeks
• smaller total lacunocanalicular area in tibia at age 6 weeks
abnormal articular cartilage morphology ( J:344727 )
• increased number of chondrocyte clusters, with greater number of chondrocytes per cluster, in articular cartilage of tibia at age 6 weeks
• thicker in tibia at age 6 weeks

growth/size/body
growth/size/body region phenotype ( J:344727 )
N
• normal size




Genotype
MGI:7615088
ot3
Allelic
Composition		 Mbtps2em2Sapo/Y
Genetic
Background		 involves: C57BL/6J * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mbtps2em2Sapo mutation (0 available); any Mbtps2 mutation (13 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory