All Phenotypes Mbtps2<em1Sapo> MGI Mouse

Phenotypes associated with this allele

Allelic Composition	Mbtps2^em1Sapo/Mbtps2^em1Sapo
Genetic Background	C57BL/6J-Mbtps2^em1Sapo

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mbtps2^em1Sapo mutation (0 available); any Mbtps2 mutation (13 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

• no embryos found at E6.5, E8.5, E12.5 or E15.5

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

skeleton phenotype ( J:344727 )

N	• normal growth plate length • no osteoarthritic phenotype in articular cartilage of tibia at age 12 weeks • normal bone mineralization heterogeneity in tibia at age 12 weeks • normal osteocyte lacunar number and area in tibia at age 12 weeks

• in tibia at age 12 weeks

• fewer and shorter canaliculi in tibia at age 12 weeks

• smaller total lacunocanalicular area in tibia at age 12 weeks

• decreased mineralization in tibia at age 12 weeks

increased chondrocyte number ( J:344727 )

• increased number of chondrocyte clusters, with greater number of chondrocytes per cluster, in articular cartilage of tibia at age 12 weeks

• increased number of chondrocyte clusters, with greater number of chondrocytes per cluster, in articular cartilage of tibia at age 12 weeks

• thicker in tibia at age 12 weeks

• no osteoarthritic phenotype in articular cartilage of tibia at age 12 weeks

decreased bone mineralization ( J:344727 )

• hypomineralized subchondral and trabecular bone in tibia at age 12 weeks

• normal bone mineralization heterogeneity in tibia at age 12 weeks

• normal osteocyte lacunar number and area in tibia at age 12 weeks

growth/size/body

growth/size/body region phenotype ( J:344727 )

N	• normal size

Allelic Composition	Mbtps2^em1Sapo/Y
Genetic Background	C57BL/6J-Mbtps2^em1Sapo

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mbtps2^em1Sapo mutation (0 available); any Mbtps2 mutation (13 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

• no embryos found at E6.5, E8.5, E12.5 or E15.5

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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