Phenotypes associated with this allele

• Allele Symbol: Thoc6^em1Schaf
• Allele Name: endonuclease-mediated mutation 1, Ashleigh Schaffer
• Allele ID: MGI:7610212
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Thoc6^em1Schaf/Thoc6^em1Schaf	C57BL/6JN-Thoc6^em1Schaf	MGI:7610493
ht2	Thoc6^em1Schaf/Thoc6^+	C57BL/6JN-Thoc6^em1Schaf	MGI:7610501

Genotype
MGI:7610493

hm1

• Allelic Composition: Thoc6^em1Schaf/Thoc6^em1Schaf
• Genetic Background: C57BL/6JN-Thoc6^em1Schaf

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:345604 )

• embryonic lethality by E11.5

growth/size/body

embryonic growth retardation ( J:345604 )

• a delay in embryo development is seen by E9.5

decreased embryo size ( J:345604 )

• embryos are smaller by E9.5

embryo

increased embryonic tissue cell apoptosis ( J:345604 )

• E9.5 neuroepithelium shows widespread apoptosis

embryonic growth retardation ( J:345604 )

• a delay in embryo development is seen by E9.5

decreased embryo size ( J:345604 )

• embryos are smaller by E9.5

nervous system

abnormal telencephalon development ( J:345604 )

• thinner epithelium is seen in the telencephalic vesicles of E8.5-E10.5 embryos

• however, curvature of the embryonic trunk and axial rotation occurs, indicating normal differentiation of germinal layers during development

increased embryonic neuroepithelial cell proliferation ( J:345604 )

• E9.5 neuroepithelium shows an increase in mitotically active cells

cellular

increased embryonic tissue cell apoptosis ( J:345604 )

• E9.5 neuroepithelium shows widespread apoptosis

Genotype
MGI:7610501

ht2

• Allelic Composition: Thoc6^em1Schaf/Thoc6⁺
• Genetic Background: C57BL/6JN-Thoc6^em1Schaf

normal phenotype

no abnormal phenotype detected ( J:345604 )

• mice do not exhibit overt phenotypes