All Phenotypes Orm2<em1Bcgen> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Orm2^em1Bcgen
endonuclease-mediated mutation 1, Biocytogen LLC
MGI:7607189

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Orm2^em1Bcgen/Orm2^em1Bcgen	involves: C57BL/6J	MGI:7607204
ht2	Orm2^em1Bcgen/Orm2⁺	involves: C57BL/6J	MGI:7607206

Allelic Composition	Orm2^em1Bcgen/Orm2^em1Bcgen
Genetic Background	involves: C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Orm2^em1Bcgen mutation (0 available); any Orm2 mutation (12 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

liver inflammation ( J:333118 )

• increased expression of hepatic inflammatory genes on a high fat diet

• increased abundance of F4/80-positive macrophages

adipose tissue

adipose tissue phenotype ( J:333118 )

N	• no difference in body weight, leptin concentrations, inguinal white adipose tissue, and brown adipose tissue on a high fat diet compared to diet matched controls

growth/size/body

increased liver weight ( J:333118 )

• increase in liver to body weight ratio when on a normal chow diet

• also on a high cholesterol and high fructose in male mice compared to diet matched controls

homeostasis/metabolism

increased circulating LDL cholesterol level ( J:333118 )

• on a high fat diet

increased circulating triglyceride level ( J:333118 )

• increased plasma levels when on a normal chow diet

• on a high cholesterol and high fructose diet in males

increased circulating alanine transaminase level ( J:333118 )

• on a high fat diet

• on a high cholesterol and high fructose diet in males

increased circulating aspartate transaminase level ( J:333118 )

• on a high fat diet

• on a high cholesterol and high fructose diet in males

increased liver triglyceride level ( J:333118 )

• when on a normal chow diet

• on a high cholesterol and high fructose diet in males

liver/biliary system

increased liver weight ( J:333118 )

• increase in liver to body weight ratio when on a normal chow diet

• also on a high cholesterol and high fructose in male mice compared to diet matched controls

increased liver triglyceride level ( J:333118 )

• when on a normal chow diet

• on a high cholesterol and high fructose diet in males

liver inflammation ( J:333118 )

• increased expression of hepatic inflammatory genes on a high fat diet

• increased abundance of F4/80-positive macrophages

hepatic steatosis ( J:333118 )

• develop more aggravated hepatic steatosis on a high fat diet compared to diet matched controls

• males develop more aggravated hepatic steatosis on high cholesterol and high fructose compared to diet matched controls

liver fibrosis ( J:333118 )

Allelic Composition	Orm2^em1Bcgen/Orm2⁺
Genetic Background	involves: C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Orm2^em1Bcgen mutation (0 available); any Orm2 mutation (12 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

liver/biliary system

increased liver triglyceride level ( J:333118 )

• on a high cholesterol and high fructose diet in males

homeostasis/metabolism

increased circulating triglyceride level ( J:333118 )

• on a high cholesterol and high fructose diet in males

increased circulating alanine transaminase level ( J:333118 )

• on a high cholesterol and high fructose diet in males

increased liver triglyceride level ( J:333118 )

• on a high cholesterol and high fructose diet in males

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/30/2024 MGI 6.23