Phenotypes associated with this allele

• Allele Symbol: Lrrn1^em1Dri
• Allele Name: endonuclease-mediated mutation 1, Elizabeth Carroll Driver
• Allele ID: MGI:7593845
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lrrn1^em1Dri/Lrrn1^em1Dri	involves: CD-1	MGI:7593854
cx2	Lrrn1^em1Dri/Lrrn1^em1Dri Notch1^tm2Agt/Notch1^+	involves: 129/Sv * C57BL/6J * CD-1	MGI:7593860

Genotype
MGI:7593854

hm1

• Allelic Composition: Lrrn1^em1Dri/Lrrn1^em1Dri
• Genetic Background: involves: CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hearing/vestibular/ear

abnormal scala media morphology ( J:344891 )

• labeling of inner phalangeal cells and border cells indicates a shift in the sensory/nonsensory boundary in the cochlear duct

increased cochlear inner hair cell number ( J:344891 )

• increase in the number of IHC doublets along the length of the epithelium

• increase is seen in the basal, mid, and apical regions, but most pronounced in the apical region

• doublets of IHCs are detectable at E14

nervous system

increased cochlear inner hair cell number ( J:344891 )

• increase in the number of IHC doublets along the length of the epithelium

• increase is seen in the basal, mid, and apical regions, but most pronounced in the apical region

• doublets of IHCs are detectable at E14

Genotype
MGI:7593860

cx2

• Allelic Composition: Lrrn1^em1Dri/Lrrn1^em1Dri; Notch1^tm2Agt/Notch1⁺
• Genetic Background: involves: 129/Sv * C57BL/6J * CD-1

hearing/vestibular/ear

abnormal cochlear inner hair cell morphology ( J:344891 )

• smaller IHC surface area

increased cochlear inner hair cell number ( J:344891 )

• number of IHC doublets is increased compared to wild-type controls and mice homozygous for Lrrn1^em1Dri and wild-type for Notch1

• increase in the number of aligned IHCs

• however, the length of the cochlea is similar to wild-type controls

nervous system

abnormal cochlear inner hair cell morphology ( J:344891 )

• smaller IHC surface area

increased cochlear inner hair cell number ( J:344891 )

• number of IHC doublets is increased compared to wild-type controls and mice homozygous for Lrrn1^em1Dri and wild-type for Notch1

• increase in the number of aligned IHCs

• however, the length of the cochlea is similar to wild-type controls