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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Trim15em2Cya
endonuclease-mediated mutation 2, Cyagen Biosciences
MGI:7587270
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Tg(Col2a1-cre/ERT)KA3Smac/0
Trim15em2Cya/Trim15em2Cya 		involves: C57BL/6J * FVB/N MGI:8474456


Genotype
MGI:8474456
cn1
Allelic
Composition		 Tg(Col2a1-cre/ERT)KA3Smac/0
Trim15em2Cya/Trim15em2Cya
Genetic
Background		 involves: C57BL/6J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Col2a1-cre/ERT)KA3Smac mutation (1 available)
Trim15em2Cya mutation (1 available); any Trim15 mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
joint inflammation ( J:365755 )
• reduced synovial inflammation in aged tamoxifen-treated mice
decreased susceptibility to induced arthritis ( J:365755 )
• protected in aged mice treated with tamoxifen with the articular cartilage relatively intact
short humerus ( J:365755 )
• in tamoxifen-treated mice
short radius ( J:365755 )
• in tamoxifen-treated mice
short ulna ( J:365755 )
• in tamoxifen-treated mice
short femur ( J:365755 )
• in tamoxifen-treated mice
short tibia ( J:365755 )
• in tamoxifen-treated mice
small vertebrae ( J:365755 )
• decreased length in first to fifth lumbar spines in tamoxifen-treated mice
abnormal chondrocyte physiology ( J:365755 )
• impaired embryonic chondrocyte senescence in mice treated with tamoxifen

growth/size/body
decreased body size ( J:365755 )
• at E13.5, E16.5, and E18.5 in tamoxifen-treated mice exposed to tamoxifen in utero

immune system
joint inflammation ( J:365755 )
• reduced synovial inflammation in aged tamoxifen-treated mice
decreased susceptibility to induced arthritis ( J:365755 )
• protected in aged mice treated with tamoxifen with the articular cartilage relatively intact

limbs/digits/tail
short humerus ( J:365755 )
• in tamoxifen-treated mice
short radius ( J:365755 )
• in tamoxifen-treated mice
short ulna ( J:365755 )
• in tamoxifen-treated mice
short femur ( J:365755 )
• in tamoxifen-treated mice
short tibia ( J:365755 )
• in tamoxifen-treated mice




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/06/2026
MGI 6.29 		The Jackson Laboratory