Analysis Tools
mortality/aging
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• lower than expected frequency of homozygotes
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behavior/neurological
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• increased latency to fall in a rotarod assay and increased maximum final speed
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• in response to intraplantar administrationof algogen formalin there is a significant reduction in the first phase responses but not the second phase
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• on a thermal gradient mice show a preference for warmer temperatures compared to wild-type controls
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• increased latency to respond to being placed on a 48oC or50oC hot plate
• however, response to a 53oC hot plate or a Hargreaves radiant heat source are similar to controls
• withdrawal response to light touch or noxious pin prick stimulus are similar to controls
• withdrawal response to noxious cold is similar to controls
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homeostasis/metabolism
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• decreased in the ventral horn of the spine but not brain
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• elevated plasma level of spermidine
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nervous system
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• no gross defects in sensory neuron survival or axon growth
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• increased levels of putrescine
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• reduced levels of spermidine
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• reduced levels of GABA in the ventral horn but not the dorsal horn
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• selective reduction in the suprathreshold excitability of IB4- nociceptors in response to static and dynamic current injections
• selective and marked hypoexcitability of C-mechano-heat-nociceptors in response to both suprathreshold mechanical stimuli and heat stimuli
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integument
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• transient white hair phenotype resulting in a 'salt and pepper' appearance of the coat between P20 and P70
• coat color is normal by P70
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pigmentation
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• transient white hair phenotype resulting in a 'salt and pepper' appearance of the coat between P20 and P70
• coat color is normal by P70
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