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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		2310057M21Rikem1Cya
endonuclease-mediated mutation 1, Cyagen Biosciences
MGI:7582056
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		2310057M21Rikem1Cya/2310057M21Rikem1Cya C57BL/6JCya-2310057M21Rikem1Cya/Cya MGI:8242712
ht2
 		2310057M21Rikem1Cya/2310057M21Rik+ C57BL/6JCya-2310057M21Rikem1Cya/Cya MGI:8242713


Genotype
MGI:8242712
hm1
Allelic
Composition		 2310057M21Rikem1Cya/2310057M21Rikem1Cya
Genetic
Background		 C57BL/6JCya-2310057M21Rikem1Cya/Cya
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
2310057M21Rikem1Cya mutation (1 available); any 2310057M21Rik mutation (19 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality, complete penetrance ( J:371549 )
• homozygous mice die during the embryonic period, time not specified




Genotype
MGI:8242713
ht2
Allelic
Composition		 2310057M21Rikem1Cya/2310057M21Rik+
Genetic
Background		 C57BL/6JCya-2310057M21Rikem1Cya/Cya
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
2310057M21Rikem1Cya mutation (1 available); any 2310057M21Rik mutation (19 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
abnormal retina vasculature morphology ( J:371549 )
• using a heat diffusion-based systems genetics algorithm to construct GWAS-derived disease networks for gene function annotation, authors predict 2310057M21Rik to be associated with retina-related diseases and report a significant increase in the mRNA and protein levels of VEGF, TGFB1, and PRKCB2 (known biomarkers of retinal conditions) in the retina at 8-12 weeks of age, suggesting changes in the vascular microcirculation and induction of an inflammatory reaction

cardiovascular system
abnormal retina vasculature morphology ( J:371549 )
• using a heat diffusion-based systems genetics algorithm to construct GWAS-derived disease networks for gene function annotation, authors predict 2310057M21Rik to be associated with retina-related diseases and report a significant increase in the mRNA and protein levels of VEGF, TGFB1, and PRKCB2 (known biomarkers of retinal conditions) in the retina at 8-12 weeks of age, suggesting changes in the vascular microcirculation and induction of an inflammatory reaction




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
08/05/2025
MGI 6.24 		The Jackson Laboratory