All Phenotypes Ergic3<tm1.1Bcgen> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ergic3^tm1.1Bcgen/Ergic3^tm1.1Bcgen	Not Specified	MGI:7594027
cx2	Ergic2^tm1.1Bcgen/Ergic2^tm1.1Bcgen Ergic3^tm1.1Bcgen/Ergic3^tm1.1Bcgen	Not Specified	MGI:7594028

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

abnormal ventricle myocardium morphology ( J:345070 )

• Cx43 signal is reduced significantly in sections of ventricular myocardium; the number and size of Cx43 gap junction plaques in ventricular myocardium are significantly reduced

enlarged heart ( J:345070 )

• homozygous mice have larger hearts than wild-type littermates

• the ratio of heart weight to body weight (HW/BW) and heart weight to tibia length (HW/TL) is increased in 3 month old homozygous mice

increased heart ventricle size ( J:345070 )

• observed in homozygous mice at 3 months of age

increased heart left ventricle size ( J:345070 )

• both left ventricular internal dimension (LVID;s) and left ventricular volume (LV Vol;s) in systole were significantly increased in homozygous mice

decreased cardiac muscle contractility ( J:345070 )

• fractional shortening (FS) is decreased in homozygous mice

decreased ventricle muscle contractility ( J:345070 )

• ejection fraction (EF) is decreased in homozygous mice

muscle

abnormal ventricle myocardium morphology ( J:345070 )

• Cx43 signal is reduced significantly in sections of ventricular myocardium; the number and size of Cx43 gap junction plaques in ventricular myocardium are significantly reduced

decreased cardiac muscle contractility ( J:345070 )

• fractional shortening (FS) is decreased in homozygous mice

decreased ventricle muscle contractility ( J:345070 )

• ejection fraction (EF) is decreased in homozygous mice

growth/size/body

growth/size/body region phenotype ( J:345070 )

N	• homozygous mice do not display any obvious alteration in growth or appearance

enlarged heart ( J:345070 )

• homozygous mice have larger hearts than wild-type littermates

• the ratio of heart weight to body weight (HW/BW) and heart weight to tibia length (HW/TL) is increased in 3 month old homozygous mice

Allelic Composition	Ergic2^tm1.1Bcgen/Ergic2^tm1.1Bcgen Ergic3^tm1.1Bcgen/Ergic3^tm1.1Bcgen
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ergic2^tm1.1Bcgen mutation (0 available); any Ergic2 mutation (41 available)
Ergic3^tm1.1Bcgen mutation (0 available); any Ergic3 mutation (20 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

enlarged heart ( J:345070 )

• homozygous mice have larger hearts than wild-type littermates

• the ratio of heart weight to body weight (HW/BW) and heart weight to tibia length (HW/TL) is increased in 3 month old homozygous mice

increased heart ventricle size ( J:345070 )

• observed in homozygous mice at 3 months of age

growth/size/body

growth/size/body region phenotype ( J:345070 )

• homozygous mice do not display any obvious alteration in growth or appearance

enlarged heart ( J:345070 )

• homozygous mice have larger hearts than wild-type littermates

• the ratio of heart weight to body weight (HW/BW) and heart weight to tibia length (HW/TL) is increased in 3 month old homozygous mice

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