Phenotypes associated with this allele

• Allele Symbol: Slc25a34^em1Duna
• Allele Name: endonuclease-mediated mutation 1, Andrew W Duncan
• Allele ID: MGI:7572931
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Slc25a34^em1Duna/Slc25a34^em1Duna	C57BL/6J-Slc25a34^em1Duna	MGI:7618988

Genotype
MGI:7618988

cn1

• Allelic Composition: Slc25a34^em1Duna/Slc25a34^em1Duna
• Genetic Background: C57BL/6J-Slc25a34^em1Duna

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

decreased circulating glucose level ( J:344152 )

• after viral cre treatment, mice fed a fast food diet for 2 months but not 6 months do not show an increase in blood glucose levels unlike in wild-type controls

decreased fasting circulating glucose level ( J:344152 )

• after viral cre treatment, mice on a fast food diet show a 25% reduction in blood glucose compared to diet matched controls

abnormal glucose tolerance ( J:344152 )

• at 1 months after viral cre injection, glucose is modestly reduced compared to controls in a glucose tolerance test

impaired glucose tolerance ( J:344152 )

• at 3 and 7 months following viral cre injection, glucose levels remain elevated for longer

• after viral cre injection in mice on a fast food diet for 2 months but is similar to controls after 6 months

insulin resistance ( J:344152 )

• after viral cre injection in mice on a fast food diet for 2 or 6 months

decreased cholesterol level ( J:344152 )

• decreased by 23% after viral cre treatment in mice on a fast food diet for 6 months compared to diet matched controls

decreased triglyceride level ( J:344152 )

• after viral cre treatment, mice fed a fast-food diet for 2 months show a 25% decrease in triglycerides compared to diet matched controls

liver/biliary system

increased liver weight ( J:344152 )

• modestly increased at 3 months after viral cre injection

hepatic steatosis ( J:344152 )

• after viral cre treatment, mice fed a fast food diet for 2 months show an increase in steatosis compared to diet matched controls

• however, after 6 months on a fast food diet total lipid area is reduced by 40% compared to diet matched controls

growth/size/body

increased body weight ( J:344152 )

• slightly increased at 1 month after viral cre injection in the liver

• increased by 15% in viral cre treated mice on a fast food diet for 6 months

increased liver weight ( J:344152 )

• modestly increased at 3 months after viral cre injection