All Phenotypes Rtl9<em2Tmki> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Rtl9^em2Tmki
endonuclease-mediated mutation 2, Tomoko Kaneko-Ishino
MGI:7571418

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rtl9^em2Tmki/Rtl9^em2Tmki	C57BL/6N-Rtl9^em2Tmki	MGI:7571429

Allelic Composition	Rtl9^em2Tmki/Rtl9^em2Tmki
Genetic Background	C57BL/6N-Rtl9^em2Tmki

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rtl9^em2Tmki mutation (0 available); any Rtl9 mutation (5 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal innate immunity ( J:343808 )

• mice show loss of fungal zymosan degradation activity in microglial lysosomes indicating impaired innate antifungal immunity

• however, zymosan is normally incorporated into lysosomes in the brain

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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