Phenotypes associated with this allele

• Allele Symbol: Cryab^em1Mtc
• Allele Name: endonuclease-mediated mutation 1, Michael T Chin
• Allele ID: MGI:7571352
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cryab^em1Mtc/Cryab^em1Mtc	involves: C57BL/6	MGI:7571390

Genotype
MGI:7571390

hm1

• Allelic Composition: Cryab^em1Mtc/Cryab^em1Mtc
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

cardiac hypertrophy ( J:342762 )

• after trans-aortic constriction (TAC)

• no hypertrophy of interventricular septum after TAC

myocardium hypertrophy ( J:342762 )

• increased cardiomyocyte hypertrophy after trans-aortic constriction (TAC)

abnormal heart left ventricle morphology ( J:342762 )

• increased maximal elastance (Emax) at age 8 and 10 weeks

• normal in 50-52-week-old mice

cardiac fibrosis ( J:342762 )

• larger areas of parenchymal fibrosis after trans-aortic constriction (TAC)

decreased ventricle muscle contractility ( J:342762 )

• reduced ejection fraction after trans-aortic constriction (TAC)

increased left ventricle diastolic pressure ( J:342762 )

• increased E/E ratio at age 25-30 weeks

growth/size/body

cardiac hypertrophy ( J:342762 )

• after trans-aortic constriction (TAC)

• no hypertrophy of interventricular septum after TAC

myocardium hypertrophy ( J:342762 )

• increased cardiomyocyte hypertrophy after trans-aortic constriction (TAC)

muscle

myocardium hypertrophy ( J:342762 )

• increased cardiomyocyte hypertrophy after trans-aortic constriction (TAC)

decreased ventricle muscle contractility ( J:342762 )

• reduced ejection fraction after trans-aortic constriction (TAC)