Phenotypes associated with this allele

• Allele Symbol: Sftpc^tm2.1Mfbs
• Allele Name: targeted mutation 2.1, Michael F Beers
• Allele ID: MGI:7550839
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Sftpc^tm2.1Mfbs/Sftpc^+	B6.Cg-Sftpc^tm2.1Mfbs	MGI:8407099

Genotype
MGI:8407099

ht1

• Allelic Composition: Sftpc^tm2.1Mfbs/Sftpc⁺
• Genetic Background: B6.Cg-Sftpc^tm2.1Mfbs

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:279196 )

• mice exhibit a median survival of 2.5 days due to lethal postnatal respiratory failure

respiratory system

lung inflammation ( J:279196 )

• lungs exhibit inflammatory infiltrate

abnormal lung morphology ( J:279196 )

• mice exhibit distorted lung architecture, enlargement of airspaces, interstitial widening, and inflammatory infiltrate

• lungs at P2 exhibit heterogenous areas of thickened septae with proteinaceous fluid in the alveolar space

abnormal lung interstitium morphology ( J:279196 )

• lungs exhibit interstitial widening

overexpanded pulmonary alveolus ( J:279196 )

respiratory distress ( J:279196 )

• respiratory distress between P1.5 and P3.5

respiratory failure ( J:279196 )

• mice develop lethal postnatal respiratory failure

immune system

lung inflammation ( J:279196 )

• lungs exhibit inflammatory infiltrate

homeostasis/metabolism

cyanosis ( J:279196 )

• cyanosis between P1.5 and P3.5

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
interstitial lung disease		DOID:3082	OMIM:PS619611	J:279196