Phenotypes associated with this allele

• Allele Symbol: Crp^em1Wuy
• Allele Name: endonuclease-mediated mutation 1, Yi Wu
• Allele ID: MGI:7545590
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Crp^em1Wuy/Crp^em1Wuy	C57BL/6-Crp^em1Wuy	MGI:7545594

Genotype
MGI:7545594

hm1

• Allelic Composition: Crp^em1Wuy/Crp^em1Wuy
• Genetic Background: C57BL/6-Crp^em1Wuy

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

abnormal susceptibility to injury induced morbidity/mortality ( J:341658 )

• increased lethality in acetaminophen-treated mice

homeostasis/metabolism

increased circulating alanine transaminase level ( J:341658 )

• in acetaminophen-treated mice

abnormal circulating aspartate transaminase level ( J:341658 )

• in acetaminophen-treated mice

abnormal susceptibility to injury induced morbidity/mortality ( J:341658 )

• increased lethality in acetaminophen-treated mice

increased susceptibility to injury ( J:341658 )

• increased acetaminophen-induced liver injury and lethality

liver/biliary system

abnormal hepatocyte morphology ( J:341658 )

• massive necrosis of hepatocytes in acetaminophen-treated mice