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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Skint2em2Htaka
endonuclease-mediated mutation 2, Hiroshi Takayanagi
MGI:7545259
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Skint2em2Htaka/Skint2em2Htaka C57BL/6-Skint2em2Htaka MGI:7545307


Genotype
MGI:7545307
hm1
Allelic
Composition		 Skint2em2Htaka/Skint2em2Htaka
Genetic
Background		 C57BL/6-Skint2em2Htaka
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Skint2em2Htaka mutation (0 available); any Skint2 mutation (30 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased dendritic epidermal T cell number ( J:291989 )
• almost complete loss of mature dendritic epidermal T cells with increases in immature CD45RBlo, CD122lo, CD24hi and CD62L+ cells

immune system
decreased dendritic epidermal T cell number ( J:291989 )
• almost complete loss of mature dendritic epidermal T cells with increases in immature CD45RBlo, CD122lo, CD24hi and CD62L+ cells

integument
decreased dendritic epidermal T cell number ( J:291989 )
• almost complete loss of mature dendritic epidermal T cells with increases in immature CD45RBlo, CD122lo, CD24hi and CD62L+ cells




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory