All Phenotypes Wdfy4<em1Jkln> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Wdfy4^em1Jkln
endonuclease-mediated mutation 1, Justin Kline
MGI:7545162

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Wdfy4^em1Jkln/Wdfy4^em1Jkln	C57BL/6J-Wdfy4^em1Jkln	MGI:7545236

Allelic Composition	Wdfy4^em1Jkln/Wdfy4^em1Jkln
Genetic Background	C57BL/6J-Wdfy4^em1Jkln

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Wdfy4^em1Jkln mutation (0 available); any Wdfy4 mutation (144 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:326216 )

N	• mice exhibit normal numbers of T cells in secondary lymphoid organs

decreased dendritic cell number ( J:326216 )

• reduced CD103+ CD11b^neg migratory cDC1 cells in the mesenteric lymph nodes

neoplasm

increased tumor growth/size ( J:326216 )

• mice fail to reject 1969 sarcoma cells unlike wild-type mice

hematopoietic system

decreased dendritic cell number ( J:326216 )

• reduced CD103+ CD11b^neg migratory cDC1 cells in the mesenteric lymph nodes

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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