All Phenotypes Elmo2<tm1.1Jfco> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Elmo2^tm1.1Jfco
targeted mutation 1.1, Jean-Francois Cote
MGI:7544996

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Elmo2^tm1.1Jfco/Elmo2^tm1.1Jfco	involves: 129 * C57BL/6	MGI:7545144
cx2	Elmo1^tm1.2Ravi/Elmo1^tm1.2Ravi Elmo2^tm1.1Jfco/Elmo2^tm1.1Jfco	involves: 129P2/OlaHsd * C57BL/6	MGI:7545145

Allelic Composition	Elmo2^tm1.1Jfco/Elmo2^tm1.1Jfco
Genetic Background	involves: 129 * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Elmo2^tm1.1Jfco mutation (0 available); any Elmo2 mutation (37 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:331473 )

• mice are viable with no gross abnormalities with normal muscle morphology and regeneration

Allelic Composition	Elmo1^tm1.2Ravi/Elmo1^tm1.2Ravi Elmo2^tm1.1Jfco/Elmo2^tm1.1Jfco
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Elmo1^tm1.2Ravi mutation (0 available); any Elmo1 mutation (58 available)
Elmo2^tm1.1Jfco mutation (0 available); any Elmo2 mutation (37 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

preweaning lethality, incomplete penetrance ( J:331473 )

• fewer than expected mice are present at weaning

muscle

abnormal muscle development ( J:331473 )

• reduced number of nuclei per myofiber indicating less fusion

decreased skeletal muscle fiber size ( J:331473 )

impaired skeletal muscle regeneration ( J:331473 )

• following cardiotoxin-induced injury

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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