All Phenotypes Arrdc5<em1Oat> MGI Mouse

reproductive system phenotype ( J:336766 )

N	• female mice exhibit normal fertility

oligozoospermia ( J:336766 )

teratozoospermia ( J:336766 , J:379207 )

• malformed acrosomes, misshapen equatorial segments, lack of hook rims, flattened heads, and retained cytoplasm (J:336766)

• while morphology of spermatozoa in seminiferous tubules appears normal, in the caput epididymis, spermatozoa with both bent and unbent necks are seen, and in the cauda epididymis, majority of spermatozoa exhibit bent necks (J:379207)

abnormal acrosome morphology ( J:336766 )

enlarged sperm head ( J:336766 )

• enlarged and flattened

asthenozoospermia ( J:336766 )

abnormal spermiogenesis ( J:336766 , J:379207 )

(J:336766)

• cytoplasmic droplet formation initiates during spermiogenesis but incorporation of saccular elements is impaired and proper migration is blocked during epididymal transit (J:379207)

• caput spermatozoa with unbent necks exhibit a distinguishable bulb (the cytoplasmic droplet) in the neck region compared to wild-type in which the cytoplasmic droplet in most caput sperm already migrated to the flagellar body (J:379207)

• in cauda epididymides, none of the sperm have cytoplasmic droplets properly positioned at the midpiece, with most retained in the neck region (J:379207)

• the retained cytoplasmic droplets of epididymal sperm remain attached to sperm heads and lack saccular elements, however vesicular components are seen in the cytoplasm of spermatids (J:379207)

impaired sperm capacitation ( J:336766 )

male infertility ( J:336766 )

• male mice fail to produce offspring

impaired acrosome reaction ( J:336766 )

impaired sperm penetration of zona pellucida ( J:336766 )

• with some capacity for fusion with the oocyte plasma membrane and activation when the zona pellucida is removed