Phenotypes associated with this allele

• Allele Symbol: Discn^em1Zhgp
• Allele Name: endonuclease-mediated mutation 1, Ping Zheng
• Allele ID: MGI:7541191
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Discn^em1Zhgp/Discn^em1Zhgp	C57BL/6J-Discn^em1Zhgp	MGI:7541194

Genotype
MGI:7541194

hm1

• Allelic Composition: Discn^em1Zhgp/Discn^em1Zhgp
• Genetic Background: C57BL/6J-Discn^em1Zhgp

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:340217 )

• more than half of mice die within one week after birth

behavior/neurological

abnormal long-term spatial reference memory ( J:340217 )

• compromised long term memory in a Morris water maze

increased anxiety-related response ( J:340217 )

• mice spend less time in the light half in a light-dark box test

increased thigmotaxis ( J:340217 )

• in an open field, mice spend less time in the center and crossing the center compared with wild-type mice

increased grooming behavior ( J:340217 )

impaired coordination ( J:340217 )

nervous system

abnormal brain morphology ( J:340217 )

• increased double strand breaks in the brain with increased immune reaction based on gene expression