All Phenotypes Tnni3k<A> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tnni3k^A
A
MGI:7540645

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Tg(Myh6-CASQ2)1Mord/0 Tnni3k^B/Tnni3k^A	involves: AKR/J * DBA/2J	MGI:7540821

Allelic Composition	Tg(Myh6-CASQ2)1Mord/0 Tnni3k^B/Tnni3k^A
Genetic Background	involves: AKR/J * DBA/2J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Myh6-CASQ2)1Mord mutation (0 available)
Tnni3k^A mutation (0 available); any Tnni3k mutation (47 available)
Tnni3k^B mutation (0 available); any Tnni3k mutation (47 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

decreased cardiac muscle contractility ( J:154116 )

• reduced fractional shortening at age 4 and 8 weeks

mortality/aging

extended life span ( J:154116 )

• average 107-day survival (vs 40 days for homozygous Tnni3k (WT) with transgene)

muscle

decreased cardiac muscle contractility ( J:154116 )

• reduced fractional shortening at age 4 and 8 weeks

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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