Phenotypes associated with this allele

• Allele Symbol: Tg(Myh6-TNNI3K)#Dmar
• Allele Name: transgene insertion, Douglas A Marchuk
• Allele ID: MGI:7539752
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Tg(Myh6-CASQ2)1Mord/0 Tg(Myh6-TNNI3K)#Dmar/0 Tnni3k^B/Tnni3k^B	involves: C57BL/6J * DBA/2J * SJL/J	MGI:7540832
cx2	Tg(Myh6-TNNI3K)#Dmar/0 Tnni3k^B/Tnni3k^B	involves: C57BL/6J * DBA/2J * SJL/J	MGI:7540837

Genotype
MGI:7540832

cx1

• Allelic Composition: Tg(Myh6-CASQ2)1Mord/0; Tg(Myh6-TNNI3K)#Dmar/0; Tnni3k^B/Tnni3k^B
• Genetic Background: involves: C57BL/6J * DBA/2J * SJL/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

dilated cardiomyopathy ( J:154116 )

• at around age 14 days

decreased cardiac muscle contractility ( J:154116 )

• reduced fractional shortening at around age 14 days

decreased heart rate ( J:154116 )

• at around age 14 days

mortality/aging

premature death ( J:154116 )

• average 21-day survival (vs 40 days for homozygous Tnni3k (WT) with CASQ2 transgene only)

muscle

dilated cardiomyopathy ( J:154116 )

• at around age 14 days

decreased cardiac muscle contractility ( J:154116 )

• reduced fractional shortening at around age 14 days

Genotype
MGI:7540837

cx2

• Allelic Composition: Tg(Myh6-TNNI3K)#Dmar/0; Tnni3k^B/Tnni3k^B
• Genetic Background: involves: C57BL/6J * DBA/2J * SJL/J

cardiovascular system

increased response of heart to induced stress ( J:154116 )

• increased left-ventricular end diastolic diameter (LVEDD) and left-ventricular end systolic diameter (LVESD) after transverse aortic constriction (TAC)

• reduced fractional shortening at age 4 and 8 weeks after TAC

homeostasis/metabolism

increased response of heart to induced stress ( J:154116 )

• increased left-ventricular end diastolic diameter (LVEDD) and left-ventricular end systolic diameter (LVESD) after transverse aortic constriction (TAC)

• reduced fractional shortening at age 4 and 8 weeks after TAC