Phenotypes associated with this allele

• Allele Symbol: Tnni3k^B
• Allele Name: B
• Allele ID: MGI:7539710
• Summary: 5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tnni3k^B/Tnni3k^B	involves: C57BL/6J * DBA/2J	MGI:7540879
cx2	Tg(Myh6-CASQ2)1Mord/0 Tnni3k^B/Tnni3k^A	involves: AKR/J * DBA/2J	MGI:7540821
cx3	Tg(Myh6-CASQ2)1Mord/0 Tnni3k^B/Tnni3k^B	involves: AKR/J * DBA/2J	MGI:7540830
cx4	Tg(Myh6-CASQ2)1Mord/0 Tg(Myh6-TNNI3K)#Dmar/0 Tnni3k^B/Tnni3k^B	involves: C57BL/6J * DBA/2J * SJL/J	MGI:7540832
cx5	Tg(Myh6-TNNI3K)#Dmar/0 Tnni3k^B/Tnni3k^B	involves: C57BL/6J * DBA/2J * SJL/J	MGI:7540837

Genotype
MGI:7540879

hm1

• Allelic Composition: Tnni3k^B/Tnni3k^B
• Genetic Background: involves: C57BL/6J * DBA/2J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

decreased heart left ventricle posterior wall thickness ( J:339644 )

• reduced left ventricular posterior wall thickness at end-diastole (LVPW)

dilated heart left ventricle ( J:339644 )

decreased cardiac muscle contractility ( J:339644 )

• reduced fractional shortening

decreased heart rate ( J:339644 )

homeostasis/metabolism

hyperglycemia ( J:339644 )

decreased circulating insulin level ( J:339644 )

insulin resistance ( J:339644 )

• reduced insulin response after oral glucose administration

muscle

decreased cardiac muscle contractility ( J:339644 )

• reduced fractional shortening

Genotype
MGI:7540821

cx2

• Allelic Composition: Tg(Myh6-CASQ2)1Mord/0; Tnni3k^B/Tnni3k^A
• Genetic Background: involves: AKR/J * DBA/2J

cardiovascular system

decreased cardiac muscle contractility ( J:154116 )

• reduced fractional shortening at age 4 and 8 weeks

mortality/aging

extended life span ( J:154116 )

• average 107-day survival (vs 40 days for homozygous Tnni3k (WT) with transgene)

muscle

decreased cardiac muscle contractility ( J:154116 )

• reduced fractional shortening at age 4 and 8 weeks

Genotype
MGI:7540830

cx3

• Allelic Composition: Tg(Myh6-CASQ2)1Mord/0; Tnni3k^B/Tnni3k^B
• Genetic Background: involves: AKR/J * DBA/2J

mortality/aging

extended life span ( J:154116 )

• average 150-day survival (vs 40 days for homozygous Tnni3k (WT) with transgene)

Genotype
MGI:7540832

cx4

• Allelic Composition: Tg(Myh6-CASQ2)1Mord/0; Tg(Myh6-TNNI3K)#Dmar/0; Tnni3k^B/Tnni3k^B
• Genetic Background: involves: C57BL/6J * DBA/2J * SJL/J

cardiovascular system

dilated cardiomyopathy ( J:154116 )

• at around age 14 days

decreased cardiac muscle contractility ( J:154116 )

• reduced fractional shortening at around age 14 days

decreased heart rate ( J:154116 )

• at around age 14 days

mortality/aging

premature death ( J:154116 )

• average 21-day survival (vs 40 days for homozygous Tnni3k (WT) with CASQ2 transgene only)

muscle

dilated cardiomyopathy ( J:154116 )

• at around age 14 days

decreased cardiac muscle contractility ( J:154116 )

• reduced fractional shortening at around age 14 days

Genotype
MGI:7540837

cx5

• Allelic Composition: Tg(Myh6-TNNI3K)#Dmar/0; Tnni3k^B/Tnni3k^B
• Genetic Background: involves: C57BL/6J * DBA/2J * SJL/J

cardiovascular system

increased response of heart to induced stress ( J:154116 )

• increased left-ventricular end diastolic diameter (LVEDD) and left-ventricular end systolic diameter (LVESD) after transverse aortic constriction (TAC)

• reduced fractional shortening at age 4 and 8 weeks after TAC

homeostasis/metabolism

increased response of heart to induced stress ( J:154116 )

• increased left-ventricular end diastolic diameter (LVEDD) and left-ventricular end systolic diameter (LVESD) after transverse aortic constriction (TAC)

• reduced fractional shortening at age 4 and 8 weeks after TAC