Phenotypes associated with this allele

• Allele Symbol: Mirc24^em1Jtm
• Allele Name: endonuclease-mediated mutation 1, Joshua T Mendell
• Allele ID: MGI:7537131
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Mirc24^em1Jtm/Mirc24^em1Jtm Zswim8^em1Jtm/Zswim8^em1Jtm	C57BL/6J-Zswim8^em1Jtm Mirc24^em1Jtm	MGI:7537173
cx2	Mirc24^em1Jtm/Y Zswim8^em1Jtm/Zswim8^em1Jtm	C57BL/6J-Zswim8^em1Jtm Mirc24^em1Jtm	MGI:7537174

Genotype
MGI:7537173

cx1

• Allelic Composition: Mirc24^em1Jtm/Mirc24^em1Jtm; Zswim8^em1Jtm/Zswim8^em1Jtm
• Genetic Background: C57BL/6J-Zswim8^em1Jtm Mirc24^em1Jtm

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:338912 )

• die shortly after birth

respiratory system

abnormal lung development ( J:338912 )

• neonates have immature lungs at the late canalicular stage

cardiovascular system

ventricular septal defect ( J:338912 )

globular heart ( J:338912 )

• globose in shape lacking a distinct apex

growth/size/body

growth/size/body region phenotype ( J:338912 )

• loss of expression of Mir322 and Mir503 rescues the prenatal growth defect

Genotype
MGI:7537174

cx2

• Allelic Composition: Mirc24^em1Jtm/Y; Zswim8^em1Jtm/Zswim8^em1Jtm
• Genetic Background: C57BL/6J-Zswim8^em1Jtm Mirc24^em1Jtm

mortality/aging

neonatal lethality, complete penetrance ( J:338912 )

• die shortly after birth

respiratory system

abnormal lung development ( J:338912 )

• neonates have immature lungs at the late canalicular stage

cardiovascular system

ventricular septal defect ( J:338912 )

globular heart ( J:338912 )

• globose in shape lacking a distinct apex

growth/size/body

growth/size/body region phenotype ( J:338912 )

N • loss of expression of Mir322 and Mir503 rescues the prenatal growth defect