All Phenotypes 1700010I14Rik<em1Osb> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	1700010I14Rik^em1Osb/1700010I14Rik^em1Osb	involves: C57BL/6J * DBA/2J	MGI:7531571
cx2	1700010I14Rik^em1Osb/1700010I14Rik^em1Osb Tsnaxip1^em1Osb/Tsnaxip1^em1Osb	involves: C57BL/6J * DBA/2J	MGI:7531572

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

decreased hyperactivated sperm motility ( J:340908 )

• spermatozoa exhibit low maximum bending angles of the midpiece in primary anti-hook curvature in capacitating medium, indicating impaired hyperactivation

decreased sperm progressive motility ( J:340908 )

• percentage of progressively motile spermatozoa is reduced, likely due to their circular motion

• however, mice do not exhibit a reduction in the percentage of motile spermatozoa

• velocity parameters of spermatozoa, including average path velocity, straight-line velocity, and curvilinear velocity, are impaired

• flagellar beating pattern of spermatozoa shows an asymmetric waveform

reduced male fertility ( J:340908 )

• males exhibit impaired fertility

• however, no abnormalities are seen in gross morphology or weight of the testis or in spermatozoa

cellular

decreased hyperactivated sperm motility ( J:340908 )

• spermatozoa exhibit low maximum bending angles of the midpiece in primary anti-hook curvature in capacitating medium, indicating impaired hyperactivation

decreased sperm progressive motility ( J:340908 )

• percentage of progressively motile spermatozoa is reduced, likely due to their circular motion

• however, mice do not exhibit a reduction in the percentage of motile spermatozoa

• velocity parameters of spermatozoa, including average path velocity, straight-line velocity, and curvilinear velocity, are impaired

• flagellar beating pattern of spermatozoa shows an asymmetric waveform

Allelic Composition	1700010I14Rik^em1Osb/1700010I14Rik^em1Osb Tsnaxip1^em1Osb/Tsnaxip1^em1Osb
Genetic Background	involves: C57BL/6J * DBA/2J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
1700010I14Rik^em1Osb mutation (2 available); any 1700010I14Rik mutation (37 available)
Tsnaxip1^em1Osb mutation (2 available); any Tsnaxip1 mutation (31 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

decreased hyperactivated sperm motility ( J:340908 )

• spermatozoa exhibit low maximum bending angles of the midpiece in primary anti-hook

• curvature in capacitating medium, indicating impaired hyperactivation

decreased sperm progressive motility ( J:340908 )

• spermatozoa exhibit impaired motility with circular travel paths

• flagellar beating pattern of spermatozoa shows an asymmetric waveform

reduced male fertility ( J:340908 )

• mice exhibit impaired fertility but are not infertile

• however, spermatozoa exhibit normal morphology

cellular

decreased hyperactivated sperm motility ( J:340908 )

• spermatozoa exhibit low maximum bending angles of the midpiece in primary anti-hook

• curvature in capacitating medium, indicating impaired hyperactivation

decreased sperm progressive motility ( J:340908 )

• spermatozoa exhibit impaired motility with circular travel paths

• flagellar beating pattern of spermatozoa shows an asymmetric waveform

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 05/07/2024 MGI 6.23