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Allele Symbol Allele Name Allele ID |
Nsftm1Himat targeted mutation 1, Hideo Matsuzaki MGI:7531287 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• in the light/dark box test, mice exhibit a longer latency to enter the light box, indicting increased anxiety
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• vertical activity is increased in the open-field test, indicating repetitive behavior
• however, no difference in the total distance traveled is seen in the open-field test
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• in a three-chamber social interaction test, mice show less interaction with the stranger mouse during session 2 of the test
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• at P6, pups emit fewer calls than wild-type pups
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• mice show a decrease in postsynaptic density area in postsynaptic membrane of hippocampal -CA1 region
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• elevation of fEPSPs upon induction of long term depression (LTD) by low-frequency stimulation of Schaffer collaterals is deceased in hippocampal CA1 neurons
• however, no change in the fEPSPs is seen upon induction of long term potentiation (LTP) by high-frequency stimulation of Schaffer collaterals and no difference is seen in basal synaptic function
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| autism spectrum disorder | DOID:0060041 | J:313900 | ||
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/14/2024 MGI 6.23 |
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