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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Polr1aem1Knwea
endonuclease-mediated mutation 1, Kathryn Nicole Weaver
MGI:7526140
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Polr1aem1Knwea/Polr1aem1Knwea C57BL/6-Polr1aem1Knwea MGI:7526443
ht2
 		Polr1aem1Knwea/Polr1a+ C57BL/6-Polr1aem1Knwea MGI:7526438
cn3
 		Foxg1tm1.1(cre)Ddmo/0
Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sor+
Polr1aem1Knwea/Polr1atm1c(EUCOMM)Hmgu 		involves: 129S1/Sv * 129T/Sv * 129X1/SvJ * C57BL/6N MGI:7526484
cn4
 		Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sor+
Polr1aem1Knwea/Polr1atm1c(EUCOMM)Hmgu
Tg(Wnt1-cre/Esr1*)10Rth/0 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6N MGI:7526471
cn5
 		Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sor+
Polr1aem1Knwea/Polr1atm1c(EUCOMM)Hmgu
Tg(Sox10-cre)1Wdr/0 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6N * CBA MGI:7526470


Genotype
MGI:7526443
hm1
Allelic
Composition		 Polr1aem1Knwea/Polr1aem1Knwea
Genetic
Background		 C57BL/6-Polr1aem1Knwea
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Polr1aem1Knwea mutation (0 available); any Polr1a mutation (93 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging




Genotype
MGI:7526438
ht2
Allelic
Composition		 Polr1aem1Knwea/Polr1a+
Genetic
Background		 C57BL/6-Polr1aem1Knwea
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Polr1aem1Knwea mutation (0 available); any Polr1a mutation (93 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
embryo
embryo phenotype ( J:335489 )
N
• mice born at expected Mendelian ratios and normal sex ratio

growth/size/body
growth/size/body region phenotype ( J:335489 )
N
• no obvious phenotype

reproductive system




Genotype
MGI:7526484
cn3
Allelic
Composition		 Foxg1tm1.1(cre)Ddmo/0
Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sor+
Polr1aem1Knwea/Polr1atm1c(EUCOMM)Hmgu
Genetic
Background		 involves: 129S1/Sv * 129T/Sv * 129X1/SvJ * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxg1tm1.1(cre)Ddmo mutation (1 available); any Foxg1 mutation (28 available)
Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo mutation (10 available); any Gt(ROSA)26Sor mutation (944 available)
Polr1aem1Knwea mutation (0 available); any Polr1a mutation (93 available)
Polr1atm1c(EUCOMM)Hmgu mutation (0 available); any Polr1a mutation (93 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
telencephalon hypoplasia ( J:335489 )
• in E14 and E17 embryos
• normal in E12 embryos




Genotype
MGI:7526471
cn4
Allelic
Composition		 Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sor+
Polr1aem1Knwea/Polr1atm1c(EUCOMM)Hmgu
Tg(Wnt1-cre/Esr1*)10Rth/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo mutation (10 available); any Gt(ROSA)26Sor mutation (944 available)
Polr1aem1Knwea mutation (0 available); any Polr1a mutation (93 available)
Polr1atm1c(EUCOMM)Hmgu mutation (0 available); any Polr1a mutation (93 available)
Tg(Wnt1-cre/Esr1*)10Rth mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

craniofacial
flat forehead ( J:335489 )
• starting in E9.5 embryos, worsening with age

growth/size/body
flat forehead ( J:335489 )
• starting in E9.5 embryos, worsening with age
facial cleft ( J:335489 )

cardiovascular system
cardiovascular system phenotype ( J:335489 )
N
• normal outflow tract septation in E12 embryos




Genotype
MGI:7526470
cn5
Allelic
Composition		 Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sor+
Polr1aem1Knwea/Polr1atm1c(EUCOMM)Hmgu
Tg(Sox10-cre)1Wdr/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6N * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo mutation (10 available); any Gt(ROSA)26Sor mutation (944 available)
Polr1aem1Knwea mutation (0 available); any Polr1a mutation (93 available)
Polr1atm1c(EUCOMM)Hmgu mutation (0 available); any Polr1a mutation (93 available)
Tg(Sox10-cre)1Wdr mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
craniofacial
midline cleft upper lip ( J:335489 )
• median lip notches in some E14-E15 embryos
cleft palate ( J:335489 )
• in some E14-E15 embryos
facial cleft ( J:335489 )
• in some E14-E15 embryos

digestive/alimentary system
cleft palate ( J:335489 )
• in some E14-E15 embryos

growth/size/body
midline cleft upper lip ( J:335489 )
• median lip notches in some E14-E15 embryos
cleft palate ( J:335489 )
• in some E14-E15 embryos
facial cleft ( J:335489 )
• in some E14-E15 embryos




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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory