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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Il17bem1Cya
endonuclease-mediated mutation 1, Cyagen Biosciences
MGI:7522234
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Il17bem1Cya/Il17bem1Cya C57BL/6-Il17bem1Cya MGI:7522458


Genotype
MGI:7522458
hm1
Allelic
Composition		 Il17bem1Cya/Il17bem1Cya
Genetic
Background		 C57BL/6-Il17bem1Cya
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il17bem1Cya mutation (0 available); any Il17b mutation (23 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
increased susceptibility to induced colitis ( J:339366 )
• mice exhibit exacerbated DSS-induced colitis, with mice losing more weight, shorter colon lengths, greater inflammatory cell infiltration and epithelial cell destruction
• levels of inflammatory cytokines TNF, IL1B, and IL6 are increased in colon in mice with DSS-induced colitis
• mice with DSS-induced colitis show alleviation of colitis following treatment with recombinant mouse IL17B

homeostasis/metabolism
abnormal cytokine level ( J:339366 )
• levels of inflammatory cytokines TNF, IL1B, and IL6 are increased in colon in mice with DSS-induced colitis

hematopoietic system
increased neutrophil cell number ( J:339366 )
• mice with DSS-induced colitis show an altered colonic immune cell composition compared to wild-type mice with colitis, with an increase in CD11B+Ly6Ghigh neutrophil infiltration in colon lamina propria
• mice with DSS-induced colitis treated with recombinant mouse IL17B show inhibition of S100a9+ neutrophil infiltration in the colon
increased macrophage cytokine production ( J:339366 )
• colonic macrophages of mice with DSS-induced colitis show increased inflammatory response with increased production of inflammatory cytokines

immune system
increased susceptibility to induced colitis ( J:339366 )
• mice exhibit exacerbated DSS-induced colitis, with mice losing more weight, shorter colon lengths, greater inflammatory cell infiltration and epithelial cell destruction
• levels of inflammatory cytokines TNF, IL1B, and IL6 are increased in colon in mice with DSS-induced colitis
• mice with DSS-induced colitis show alleviation of colitis following treatment with recombinant mouse IL17B
increased neutrophil cell number ( J:339366 )
• mice with DSS-induced colitis show an altered colonic immune cell composition compared to wild-type mice with colitis, with an increase in CD11B+Ly6Ghigh neutrophil infiltration in colon lamina propria
• mice with DSS-induced colitis treated with recombinant mouse IL17B show inhibition of S100a9+ neutrophil infiltration in the colon
increased macrophage cytokine production ( J:339366 )
• colonic macrophages of mice with DSS-induced colitis show increased inflammatory response with increased production of inflammatory cytokines
abnormal cytokine level ( J:339366 )
• levels of inflammatory cytokines TNF, IL1B, and IL6 are increased in colon in mice with DSS-induced colitis




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory