Analysis Tools
mortality/aging
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• no mice are observed at E13.5
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Allele Symbol Allele Name Allele ID |
Rps12em1.1Nbakr endonuclease-mediated mutation 1.1, Nicholas Baker MGI:7521935 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• no mice are observed at E13.5
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• reduced self-renewal capacity in serial replating
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• with defective transition between RII and RIII stage cells in the bone marrow worsening with age
• however, erythropoiesis in the embryo and spleen is normal
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• in young mice
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• in the bone marrow
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• older mice exhibit increased in basophilic erythroblasts and late basophilic and polychromatophilic erythroblasts in the bone marrow and spleen compared with wild-type mice
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• older mice exhibit reduced orthochromatic erythroblasts in the bone marrow and spleen compared with wild-type mice
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• in young mice
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• in young mice
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• long-term and short-term in young mice
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• chronic
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• in young and older mice
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• reduced self-renewal capacity in serial replating
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• in young mice
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• in young and older mice
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/07/2024 MGI 6.23 |
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