Phenotypes associated with this allele

• Allele Symbol: Septin2^{tm1c(EUCOMM)Wtsi}
• Allele Name: targeted mutation 1c, Wellcome Trust Sanger Institute
• Allele ID: MGI:7520266
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Septin2^tm1c(EUCOMM)Wtsi/Septin2^tm1c(EUCOMM)Wtsi Cnp^tm1(cre)Kan/Cnp^+	involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6N	MGI:7523331
cn2	Septin2^tm1c(EUCOMM)Wtsi/Septin2^tm1c(EUCOMM)Wtsi Tg(Dhh-cre)1Mejr/0	involves: 129S4/SvJaeSor * C57BL/6N * FVB/N	MGI:7523329

Genotype
MGI:7523331

cn1

• Allelic Composition: Septin2^{tm1c(EUCOMM)Wtsi}/Septin2^{tm1c(EUCOMM)Wtsi}; Cnp^tm1(cre)Kan/Cnp⁺
• Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6N
• Cell Lines: EPD0175_4_D03

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal sciatic nerve morphology ( J:339068 )

• while the abundance of SEPTIN2 is markedly reduced in sciatic nerve lysates as expected, the abundance of other septin subunits expressed in PNS myelin (SEPTIN7, SEPTIN8, SEPTIN9, and SEPTIN11) is also substantially lower than that in sciatic nerve lysates of control mice

Genotype
MGI:7523329

cn2

• Allelic Composition: Septin2^{tm1c(EUCOMM)Wtsi}/Septin2^{tm1c(EUCOMM)Wtsi}; Tg(Dhh-cre)1Mejr/0
• Genetic Background: involves: 129S4/SvJaeSor * C57BL/6N * FVB/N
• Cell Lines: EPD0175_4_D03

nervous system

nervous system phenotype ( J:339068 )

N • P14 sciatic nerves show no significant change in the number of normal-appearing myelinated axons; no axonal degeneration is noted and the number of myelin outfoldings is similar to that in control mice, indicating normal biogenesis of PNS myelin

N • P75 sciatic nerves show similar abundance of myelin proteins (MAG, CNP, P0/MPZ, PMP22) relative to control mice

N • motor nerve conduction velocity (mNCV) in sciatic nerves and sensory nerve conduction velocity (sNCV) in the tail nerve are slightly but not significantly decreased at 1 year of age

abnormal sciatic nerve morphology ( J:339068 )

• while the abundance of SEPTIN2 is markedly reduced in sciatic nerve lysates as expected, the abundance of other septin subunits expressed in PNS myelin (SEPTIN7, SEPTIN8, SEPTIN9, and SEPTIN11) is also substantially lower than that in the sciatic nerve lysates of control mice

behavior/neurological

behavior/neurological phenotype ( J:339068 )

• mice show no alterations in the latency of retracting a hindpaw upon a mechanical stimulus (plantar test) at 32 weeks of age or in the latency of falling from an accelerating rotating rod at 6 months of age