All Phenotypes Card19<tm1Rwen> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Card19^tm1Rwen/Card19^tm1Rwen	involves: 129P2/OlaHsd * C57BL/6	MGI:7514949
cx2	Card19^tm1Rwen/Card19^tm1Rwen Tg(IghelMD4)4Ccg/0	involves: 129P2/OlaHsd * C57BL/6	MGI:7514984
cx3	Card19^tm1Rwen/Card19^tm1Rwen Tg(IghelMD4)4Ccg/0 Tg(ML5sHEL)5Ccg/0	involves: 129P2/OlaHsd * C57BL/6 * C57BL/6JSfd	MGI:7514963

Allelic Composition	Card19^tm1Rwen/Card19^tm1Rwen
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Card19^tm1Rwen mutation (0 available); any Card19 mutation (13 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:336763 )

N	• despite expression profile populations of macrophages, granulocytes, erythrocytes, and natural killer cells in the bone marrow or spleens are similar to wild-type controls

decreased autoantibody level ( J:336763 )

• decrease in self-reactive IgM and IgG at 2 months of age compared to wild-type controls

• in culture single splenic B cells from 2 month old mice produce fewer self-reactive B cells

Allelic Composition	Card19^tm1Rwen/Card19^tm1Rwen Tg(IghelMD4)4Ccg/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Card19^tm1Rwen mutation (0 available); any Card19 mutation (13 available)
Tg(IghelMD4)4Ccg mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal B cell activation ( J:336763 )

• BCR-induced IkappaBalpha phosporylation is increased in B cells

immune system

abnormal B cell activation ( J:336763 )

• BCR-induced IkappaBalpha phosporylation is increased in B cells

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased B cell apoptosis ( J:336763 )

• increased apoptosis of B cells in response to self-antigen HEL or anti-IgM stimulation

decreased B cell proliferation ( J:336763 )

• self-reactive B-cells are less proliferative in response to BCR engagement

decreased B cell number ( J:336763 )

• decrease in the B cell population in the spleen indicating enhanced B cell tolerance

increased B cell number ( J:336763 )

• increase in the frequency of gamma L chain positive splenic B cells compared to transgenic mice wild-type for Card19

hematopoietic system

increased B cell apoptosis ( J:336763 )

• increased apoptosis of B cells in response to self-antigen HEL or anti-IgM stimulation

decreased B cell proliferation ( J:336763 )

• self-reactive B-cells are less proliferative in response to BCR engagement

decreased B cell number ( J:336763 )

• decrease in the B cell population in the spleen indicating enhanced B cell tolerance

increased B cell number ( J:336763 )

• increase in the frequency of gamma L chain positive splenic B cells compared to transgenic mice wild-type for Card19

cellular

increased B cell apoptosis ( J:336763 )

• increased apoptosis of B cells in response to self-antigen HEL or anti-IgM stimulation

decreased B cell proliferation ( J:336763 )

• self-reactive B-cells are less proliferative in response to BCR engagement

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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