Phenotypes associated with this allele

• Allele Symbol: Mir503hg^em1Jina
• Allele Name: endonuclease-mediated mutation 1, Jie Na
• Allele ID: MGI:7494278
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mir503hg^em1Jina/Mir503hg^em1Jina	C57BL/6J-Mir503hg^em1Jina	MGI:7496001

Genotype
MGI:7496001

hm1

• Allelic Composition: Mir503hg^em1Jina/Mir503hg^em1Jina
• Genetic Background: C57BL/6J-Mir503hg^em1Jina

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:336590 )

N • mice exhibit normal capillaries in the renal corpuscle and lung are normal

increased myocardial fiber size ( J:336590 )

• increased cross-sectional area without an increase in numbers of cardiomyocytes at 24 weeks of age

enlarged heart ( J:336590 )

• at 24 weeks of age

increased heart weight ( J:336590 )

• at 24 weeks of age

cardiac hypertrophy ( J:336590 )

• at 24 weeks of age

• with or without angiotensin II treatment

increased heart left ventricle weight ( J:336590 )

• at 24 weeks of age

• with or without angiotensin II treatment for 28 days

increased heart left ventricle wall thickness ( J:336590 )

• at 24 weeks of age

cardiac fibrosis ( J:336590 )

• at 24 weeks of age

hypertension ( J:336590 )

• at 24 weeks of age

• with or without angiotensin II treatment for 28 days

growth/size/body

enlarged heart ( J:336590 )

• at 24 weeks of age

increased heart weight ( J:336590 )

• at 24 weeks of age

cardiac hypertrophy ( J:336590 )

• at 24 weeks of age

• with or without angiotensin II treatment

cellular

abnormal mitochondrial morphology ( J:336590 )

• distorted and shrunken at 24 weeks of age

muscle

increased myocardial fiber size ( J:336590 )

• increased cross-sectional area without an increase in numbers of cardiomyocytes at 24 weeks of age