About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Slfn4tm1c(EUCOMM)Wtsi
targeted mutation 1c, Wellcome Trust Sanger Institute
MGI:7493861
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Slfn4tm1c(EUCOMM)Wtsi/Slfn4tm1c(EUCOMM)Wtsi
Gli1tm3(cre/ERT2)Alj/Gli1+ 		involves: 129S6/SvEvTac * Black Swiss * C57BL/6 * Swiss Webster MGI:7531280


Genotype
MGI:7531280
cn1
Allelic
Composition		 Slfn4tm1c(EUCOMM)Wtsi/Slfn4tm1c(EUCOMM)Wtsi
Gli1tm3(cre/ERT2)Alj/Gli1+
Genetic
Background		 involves: 129S6/SvEvTac * Black Swiss * C57BL/6 * Swiss Webster
Cell Lines EPD0746_4_G08
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gli1tm3(cre/ERT2)Alj mutation (2 available); any Gli1 mutation (48 available)
Slfn4tm1c(EUCOMM)Wtsi mutation (0 available); any Slfn4 mutation (34 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
abnormal stomach mucosa morphology ( J:337060 )
• at 4 months after inoculation with Helicobacter felis (H. felis), tamoxifen-treated mice develop significantly less Helicobacter-induced spasmolytic polypeptide-expressing metaplasia (SPEM) than 4-month-infected wild-type controls, as shown by reduced GSII-lectin staining and recovery of some H+, K+ -ATPase+ parietal cells

immune system
abnormal CD8-positive, alpha-beta cytotoxic T cell morphology ( J:337060 )
• H. felis-infected tamoxifen-treated mice show an increased population of CD8+ cytotoxic T cells in the stomach relative to infected wild-type controls
abnormal interleukin level ( J:337060 )
• H. felis-infected tamoxifen-treated mice show decreased gastric interleukin-1 alpha (IL1a) levels relative to infected controls
abnormal tumor necrosis factor level ( J:337060 )
• H. felis-infected tamoxifen-treated mice show decreased gastric TNF levels relative to infected controls
decreased susceptibility to bacterial infection ( J:337060 )
• H. felis-infected tamoxifen-treated mice show attenuated Helicobacter-induced gastric metaplasia relative to infected wild-type controls

homeostasis/metabolism
abnormal interleukin level ( J:337060 )
• H. felis-infected tamoxifen-treated mice show decreased gastric interleukin-1 alpha (IL1a) levels relative to infected controls
abnormal tumor necrosis factor level ( J:337060 )
• H. felis-infected tamoxifen-treated mice show decreased gastric TNF levels relative to infected controls

hematopoietic system
abnormal CD8-positive, alpha-beta cytotoxic T cell morphology ( J:337060 )
• H. felis-infected tamoxifen-treated mice show an increased population of CD8+ cytotoxic T cells in the stomach relative to infected wild-type controls




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory