Phenotypes associated with this allele

• Allele Symbol: Dipk1c^em1Yxy
• Allele Name: endonuclease-mediated mutation 1, Yuxin Yin
• Allele ID: MGI:7493848
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dipk1c^em1Yxy/Dipk1c^em1Yxy	C57BL/6-Dipk1c^em1Yxy	MGI:7493855

Genotype
MGI:7493855

hm1

• Allelic Composition: Dipk1c^em1Yxy/Dipk1c^em1Yxy
• Genetic Background: C57BL/6-Dipk1c^em1Yxy

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

impaired contextual conditioning behavior ( J:328853 )

• 3- to 6-month old mice exhibit decreased freezing in the contextual fear conditioning test suggesting impairment in the hippocampus-dependent fear memory

impaired long-term object recognition memory ( J:328853 )

• in the novel object recognition memory test, 3- to 6-month old mice could not differentiate the novel object from the old object, resulting in reduction in the discrimination ratio and indicating impaired reference memory

hyperactivity ( J:328853 )

• 3- to 6-month old mice exhibit higher activity in the home cage than wild-type mice, suggesting psychomotor agitation

• however, no differences in the rotarod or elevated O-maze are seen

nervous system

decreased dendritic spine density ( J:328853 )

• pyramidal neurons from the CA1 region of the hippocampus and the layer 2/3 from the medial prefrontal cortex show reduced spine density at 15-24 months of age, suggesting synapse loss

• however, mice exhibit normal gross brain morphology at 3 months of age

abnormal excitatory postsynaptic potential ( J:328853 )

• field recordings of hippocampal long-term potentiation (LTP) in the Schaffer collateral pathway show reduced excitatory postsynaptic potentials at 2 months of age

cellular

increased sensitivity to induced cell death ( J:328853 )

• under ER stress (using intraperitoneal injection of tunicamycin), mice show degeneration of cortical pyramidal neurons indicating increased vulnerability to stress-induced cell death; cortical areas have eosinophilic neurons with pyknotic nuclei and loss of Nissl substance and increased cell death in the cortex

growth/size/body

growth/size/body region phenotype ( J:328853 )

N • mice exhibit normal body weight