Phenotypes associated with this allele

• Allele Symbol: Pmepa1^em1Akt
• Allele Name: endonuclease-mediated mutation 1, Akiko Kukita
• Allele ID: MGI:7491928
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pmepa1^em1Akt/Pmepa1^em1Akt	C57BL/6N-Pmepa1^em1Akt	MGI:7545157

Genotype
MGI:7545157

hm1

• Allelic Composition: Pmepa1^em1Akt/Pmepa1^em1Akt
• Genetic Background: C57BL/6N-Pmepa1^em1Akt

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

abnormal osteoclast differentiation ( J:329578 )

• decreased osteoclastogenesis

• however, osteoblastgenesis was normal

decreased osteoclast cell number ( J:329578 )

abnormal osteoclast physiology ( J:329578 )

• deduction in eroded surface per bone surface in cancellous bone and reduced proton secretion

• however, vesicular acidification is normal

increased bone volume ( J:329578 )

decreased bone resorption ( J:329578 )

• bone resorption in vitro

immune system

abnormal osteoclast differentiation ( J:329578 )

• decreased osteoclastogenesis

• however, osteoblastgenesis was normal

decreased osteoclast cell number ( J:329578 )

abnormal osteoclast physiology ( J:329578 )

• deduction in eroded surface per bone surface in cancellous bone and reduced proton secretion

• however, vesicular acidification is normal

cellular

abnormal osteoclast differentiation ( J:329578 )

• decreased osteoclastogenesis

• however, osteoblastgenesis was normal

hematopoietic system

abnormal osteoclast differentiation ( J:329578 )

• decreased osteoclastogenesis

• however, osteoblastgenesis was normal

decreased osteoclast cell number ( J:329578 )

abnormal osteoclast physiology ( J:329578 )

• deduction in eroded surface per bone surface in cancellous bone and reduced proton secretion

• however, vesicular acidification is normal