All Phenotypes Pfn1<tm1Fgi> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Pfn1^tm1Fgi
targeted mutation 1, Fernando Gianfrancesco
MGI:7482601

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Pfn1^tm1Fgi/Pfn1⁺	involves: 129P2/OlaHsd	MGI:7482605

Allelic Composition	Pfn1^tm1Fgi/Pfn1⁺
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pfn1^tm1Fgi mutation (0 available); any Pfn1 mutation (10 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

abnormal cell morphology ( J:335495 )

• abnormal rounding of MEFs during mitosis

abnormal cell nucleus morphology ( J:335495 )

• increased frequency of micronuclei in calvaria mesenchymal cells from newborns

increased cell nucleus count ( J:335495 )

• some trinucleated calvaria mesenchymal cells from newborns and femur growth plate at age 4 months

binucleate ( J:335495 )

• 5x increase in binucleated cells in femur growth plate at age 4 months

abnormal mitotic cytokinesis ( J:335495 )

• in MEFs

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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