All Phenotypes Nicol1<em1Osb> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Nicol1^em1Osb
endonuclease-mediated mutation 1, Research Institute for Microbial Diseases, Osaka University
MGI:7470865

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nicol1^em1Osb/Nicol1^em1Osb	involves: C57BL/6NJcl * DBA/2NJcl	MGI:7470912

Allelic Composition	Nicol1^em1Osb/Nicol1^em1Osb
Genetic Background	involves: C57BL/6NJcl * DBA/2NJcl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nicol1^em1Osb mutation (1 available); any Nicol1 mutation (12 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

reproductive system phenotype ( J:335479 )

N	• female mice are fertile

epididymis degeneration ( J:335479 )

• degenerating initial segment

• however, expression of the gene in the testis rescues degeneration

male infertility ( J:335479 )

• however, expression of the gene by transgene rescues fertility

decreased fertilization frequency ( J:335479 )

• reduced fertilization of cumulus-free eggs

• however, ZP-free oocyte fertilization is normal

cellular

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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