Analysis Tools
mortality/aging
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• mice survive to weaning but fail to thrive and mice are routinely culled within the first 2 weeks after birth to prevent suffering
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digestive/alimentary system
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• distal colon exhibits severe disorganization of the mucosa
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• reduction in thickness of the muscle layers in the distal colon
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• a constriction point of variable position is seen within the colon
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• passage of feces along the large intestine is impeded
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growth/size/body
muscle
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• reduction in thickness of the muscle layers in the distal colon
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nervous system
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• myenteric ganglia are almost entirely absent in the colon
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• the plexus of Auerbach is reduced to isolated patches
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pigmentation
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• melanized choroidal cells are absent in the eyes
• however, the retinal pigmented epithelium and other cell layers appear normal
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vision/eye
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• melanized choroidal cells are absent in the eyes
• however, the retinal pigmented epithelium and other cell layers appear normal
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| Waardenburg syndrome type 4C | DOID:0110955 |
OMIM:613266 |
J:104443 | |
