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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rr253em5Kmm
endonuclease-mediated mutation 5, Kenneth M Murphy
MGI:7448466
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Rr253em5Kmm/Rr253em5Kmm C57BL/6J-Rr253em5Kmm MGI:7448522


Genotype
MGI:7448522
hm1
Allelic
Composition		 Rr253em5Kmm/Rr253em5Kmm
Genetic
Background		 C57BL/6J-Rr253em5Kmm
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rr253em5Kmm mutation (0 available); any Rr253 mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased dendritic cell number ( J:334296 )
• reduction of cDC2 numbers
increased dendritic cell number ( J:334296 )
• increase of cDC1 numbers

immune system
decreased dendritic cell number ( J:334296 )
• reduction of cDC2 numbers
increased dendritic cell number ( J:334296 )
• increase of cDC1 numbers




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory