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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Ghitmem1Ltk
endonuclease-mediated mutation 1, Institute of Laboratory Animal Science
MGI:7442770
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Ghitmem1Ltk/Ghitmem1Ltk C57BL6J-Ghitmem1Ltk MGI:7442782


Genotype
MGI:7442782
hm1
Allelic
Composition
Ghitmem1Ltk/Ghitmem1Ltk
Genetic
Background
C57BL6J-Ghitmem1Ltk
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ghitmem1Ltk mutation (0 available); any Ghitm mutation (25 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

muscle
• swollen mitochondria with disrupted cristae structure and reduced calcium ion uptake in skeletal muscles

liver/biliary system
• liver mitochondria exhibit increased basal and potassium ion-induced swelling compared with wild-type cells

behavior/neurological

cardiovascular system
N
• cardiac muscle function is normal

cellular
• swollen mitochondria with disrupted cristae structure and reduced calcium ion uptake in skeletal muscles
• however, cardiac muscle mitochondria exhibit normal function
• liver mitochondria exhibit increased basal and potassium ion-induced swelling compared with wild-type cells





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/30/2024
MGI 6.23
The Jackson Laboratory