Phenotypes associated with this allele

• Allele Symbol: Pnpla7^tm1.2Murm
• Allele Name: targeted mutation 1.2, Makoto Murakami
• Allele ID: MGI:7439460
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pnpla7^tm1.2Murm/Pnpla7^tm1.2Murm	B6.Cg-Pnpla7^tm1.2Murm	MGI:7439522

Genotype
MGI:7439522

hm1

• Allelic Composition: Pnpla7^tm1.2Murm/Pnpla7^tm1.2Murm
• Genetic Background: B6.Cg-Pnpla7^tm1.2Murm

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:333442 )

• by 3 to 4 weeks when fed standard chow dry pellet diet at weaning

• within 7 to 14 weeks in mice fed a paste diet

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:333442 )

N • mice exhibit normal insulin sensitivity and serum glucagon levels

decreased circulating glucose level ( J:333442 )

decreased circulating insulin level ( J:333442 )

decreased circulating insulin-like growth factor I level ( J:333442 )

decreased circulating leptin level ( J:333442 )

decreased circulating thyroxine level ( J:333442 )

increased circulating ketone body level ( J:333442 )

• increased beta-hydroxybutyrate

abnormal circulating triglyceride level ( J:333442 )

• reduced triglycerides in very-low- density lipoprotein and increased triglycerides in low-density lipoprotein

decreased body temperature ( J:333442 )

increased oxygen consumption ( J:333442 )

• in the light and dark phase

decreased respiratory quotient ( J:333442 )

• in the light phase; indicating increased dependence on lipids over carbohydrates as an energy source

increased liver glycogen level ( J:333442 )

• with more glycogen granules that in wild-type mice

decreased circulating adiponectin level ( J:333442 )

decreased choline level ( J:333442 )

• partially reduced glycerophosphocholine and choline levels in the kidneys

• however, levels in the brown adipose tissue, cerebrum, and blood were normal

decreased liver triglyceride level ( J:333442 )

• with smaller lipid droplets in mice fed a methionine/choline-deficient diet

liver/biliary system

increased liver glycogen level ( J:333442 )

• with more glycogen granules that in wild-type mice

decreased liver triglyceride level ( J:333442 )

• with smaller lipid droplets in mice fed a methionine/choline-deficient diet

growth/size/body

weight loss ( J:333442 )

• by 2 weeks of age

postnatal growth retardation ( J:333442 )

• when fed a paste diet

behavior/neurological

increased food intake ( J:333442 )

hyperactivity ( J:333442 )

• in the dark phase

adipose tissue

abnormal adipose tissue amount ( J:333442 )

• decreased visceral adipose tissue

decreased subcutaneous adipose tissue amount ( J:333442 )

browned white adipose tissue morphology ( J:333442 )

• non-cell-autonomous

integument

decreased subcutaneous adipose tissue amount ( J:333442 )

muscle

abnormal skeletal muscle fiber morphology ( J:333442 )

• thin

skeleton

kyphosis ( J:333442 )