Phenotypes associated with this allele

• Allele Symbol: Rr170^tm1.1Iku
• Allele Name: targeted mutation 1.1, Koichi Ikuta
• Allele ID: MGI:7439372
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rr170^tm1.1Iku/Rr170^tm1.1Iku	B6.Cg-Rr170^tm1.1Iku	MGI:7439409

Genotype
MGI:7439409

hm1

• Allelic Composition: Rr170^tm1.1Iku/Rr170^tm1.1Iku
• Genetic Background: B6.Cg-Rr170^tm1.1Iku

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

increased T cell apoptosis ( J:333539 )

• reduced survival of CD4+ and CD8+ peripheral T cells after Il7 stimulation

decreased T cell proliferation ( J:333539 )

• impaired homeostatic proliferation of naive T cells: lower absolute numbers of CFSE+ and higher proportion of CFSE-hi and lower proportion of CFSE-int and CFSE-lo CD4+ and CD8+ T cells in slowly dividing population in transplantation experiments

hematopoietic system

hematopoietic system phenotype ( J:333539 )

N • normal absolute and relative number of CLPs (common lymphoid progenitors) in Hardy fractions A-F

N • normal number of bone marrow cells

increased T cell apoptosis ( J:333539 )

• reduced survival of CD4+ and CD8+ peripheral T cells after Il7 stimulation

decreased T cell proliferation ( J:333539 )

• impaired homeostatic proliferation of naive T cells: lower absolute numbers of CFSE+ and higher proportion of CFSE-hi and lower proportion of CFSE-int and CFSE-lo CD4+ and CD8+ T cells in slowly dividing population in transplantation experiments

decreased T cell number ( J:333539 )

• reduced survival of CD4+ and CD8+ peripheral T cells after Il7 stimulation

immune system

immune system phenotype ( J:333539 )

N • normal number of bone marrow cells

N • normal absolute and relative number of CLPs (common lymphoid progenitors) in Hardy fractions A-F

increased T cell apoptosis ( J:333539 )

• reduced survival of CD4+ and CD8+ peripheral T cells after Il7 stimulation

decreased T cell proliferation ( J:333539 )

• impaired homeostatic proliferation of naive T cells: lower absolute numbers of CFSE+ and higher proportion of CFSE-hi and lower proportion of CFSE-int and CFSE-lo CD4+ and CD8+ T cells in slowly dividing population in transplantation experiments

decreased T cell number ( J:333539 )

• reduced survival of CD4+ and CD8+ peripheral T cells after Il7 stimulation