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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rr381em4Kap
endonuclease-mediated mutation 4, Dietmar J Kappes
MGI:7439138
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Rr381em4Kap/Rr381em4Kap involves: C57BL/6 MGI:7439203
cx2
 		H2dlAb1-Ea/H2dlAb1-Ea
Rr381em4Kap/Rr381em4Kap 		involves: 129S2/SvPas * C57BL/6 MGI:7439204


Genotype
MGI:7439203
hm1
Allelic
Composition		 Rr381em4Kap/Rr381em4Kap
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
absent CD8-positive, alpha-beta T cells ( J:333471 )
• no commitment of developing thymocytes to CD8+ lineage

immune system
absent CD8-positive, alpha-beta T cells ( J:333471 )
• no commitment of developing thymocytes to CD8+ lineage




Genotype
MGI:7439204
cx2
Allelic
Composition		 H2dlAb1-Ea/H2dlAb1-Ea
Rr381em4Kap/Rr381em4Kap
Genetic
Background		 involves: 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2dlAb1-Ea mutation (15 available); any H2 mutation (304 available)
Rr381em4Kap mutation (0 available); any Rr381 mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
absent CD8-positive, alpha-beta T cells ( J:333471 )
• almost complete redirection of MHC class I-specific T cells to CD4+ lineage

immune system
absent CD8-positive, alpha-beta T cells ( J:333471 )
• almost complete redirection of MHC class I-specific T cells to CD4+ lineage




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory