Phenotypes associated with this allele

• Allele Symbol: Vdac3^em1Kei
• Allele Name: endonuclease-mediated mutation 1, GemPharmatech Co., Ltd
• Allele ID: MGI:7432761
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Vdac3^em1Kei/Vdac3^em1Kei	C57BL/6J-Vdac3^em1Kei	MGI:7432897

Genotype
MGI:7432897

hm1

• Allelic Composition: Vdac3^em1Kei/Vdac3^em1Kei
• Genetic Background: C57BL/6J-Vdac3^em1Kei

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

abnormal sperm mitochondrial sheath morphology ( J:332977 )

♂ • shortened and impaired mitochondrial sheath structure and wavy motility

♂ • however, mitochondrial metabolism is normal

kinked sperm flagellum ( J:332977 )

♂

asthenozoospermia ( J:332977 )

♂

decreased testis weight ( J:332977 )

♂ • slightly

male infertility ( J:332977 )

♂

decreased fertilization frequency ( J:332977 )

♂ • complete loss of fertilization of cumulus-intact oocytes

♂ • however, sperm fertilize oocytes lacking zona pellucida

endocrine/exocrine glands

decreased testis weight ( J:332977 )

♂ • slightly

cellular

abnormal sperm mitochondrial sheath morphology ( J:332977 )

♂ • shortened and impaired mitochondrial sheath structure and wavy motility

♂ • however, mitochondrial metabolism is normal

kinked sperm flagellum ( J:332977 )

♂

asthenozoospermia ( J:332977 )

♂