Phenotypes associated with this allele

• Allele Symbol: Polr1c^{tm1c(KOMP)Wtsi}
• Allele Name: targeted mutation 1c, Wellcome Trust Sanger Institute
• Allele ID: MGI:7432633
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Polr1c^tm1c(KOMP)Wtsi/Polr1c^tm1c(KOMP)Wtsi Gt(ROSA)26Sor^tm1(cre/ERT2)Tyj/Gt(ROSA)26Sor^+	involves: 129S4/SvJae * C57BL/6J * C57BL/6N	MGI:8408506

Genotype
MGI:8408506

cn1

• Allelic Composition: Polr1c^{tm1c(KOMP)Wtsi}/Polr1c^{tm1c(KOMP)Wtsi}; Gt(ROSA)26Sor^{tm1(cre/ERT2)Tyj}/Gt(ROSA)26Sor⁺
• Genetic Background: involves: 129S4/SvJae * C57BL/6J * C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

craniofacial

abnormal craniofacial morphology ( J:381064 )

• at E12.5, embryos (tamoxifen-injected at E9.5) exhibit severe craniofacial abnormalities

abnormal craniofacial development ( J:381064 )

• at E12.5, embryos (tamoxifen-injected at E9.5) exhibit reduced neural crest derivatives and complete absence of skeletal condensations in the face

• however, the trigeminal ganglion persists in the expected position

abnormal face development ( J:381064 )

• at E12.5, embryos (tamoxifen-injected at E9.5) exhibit complete absence of skeletal condensations in the face

growth/size/body

abnormal face development ( J:381064 )

• at E12.5, embryos (tamoxifen-injected at E9.5) exhibit complete absence of skeletal condensations in the face