All Phenotypes Polr1a<tm1c(EUCOMM)Hmgu> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Polr1a^{tm1c(EUCOMM)Hmgu}
targeted mutation 1c, Helmholtz Zentrum Muenchen GmbH
MGI:7432631

Summary

15 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Foxg1^{tm1.1(cre)Ddmo}/0 Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo}/Gt(ROSA)26Sor⁺ Polr1a^em1Knwea/Polr1a^{tm1c(EUCOMM)Hmgu}	involves: 129S1/Sv * 129T/Sv * 129X1/SvJ * C57BL/6N	MGI:7526484
cn2	Foxg1^{tm1.1(cre)Ddmo}/Foxg1⁺ Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo}/Gt(ROSA)26Sor⁺ Polr1a^{tm1c(EUCOMM)Hmgu}/Polr1a^{tm1c(EUCOMM)Hmgu}	involves: 129S1/Sv * 129T/Sv * 129X1/SvJ * C57BL/6N	MGI:7526489
cn3	Foxg1^{tm1.1(cre)Ddmo}/Foxg1⁺ Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo}/Gt(ROSA)26Sor⁺ Polr1a^{tm1d(EUCOMM)Hmgu}/Polr1a^{tm1c(EUCOMM)Hmgu}	involves: 129S1/Sv * 129T/Sv * 129X1/SvJ * C57BL/6N	MGI:7526488
cn4	Foxg1^{tm1.1(cre)Ddmo}/Foxg1⁺ Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo}/Gt(ROSA)26Sor⁺ Polr1a^{tm1a(EUCOMM)Hmgu}/Polr1a^{tm1c(EUCOMM)Hmgu}	involves: 129S1/Sv * 129T/Sv * 129X1/SvJ * C57BL/6N	MGI:7526487
cn5	Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo}/Gt(ROSA)26Sor⁺ Polr1a^em1Knwea/Polr1a^{tm1c(EUCOMM)Hmgu} Tg(Wnt1-cre/Esr1*)10Rth/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6N	MGI:7526471
cn6	Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo}/Gt(ROSA)26Sor⁺ Polr1a^em1Knwea/Polr1a^{tm1c(EUCOMM)Hmgu} Tg(Sox10-cre)1Wdr/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6N * CBA	MGI:7526470
cn7	Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo}/Gt(ROSA)26Sor⁺ Polr1a^{tm1a(EUCOMM)Hmgu}/Polr1a^{tm1c(EUCOMM)Hmgu} Tg(Mef2c-cre)2Blk/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6N	MGI:7526459
cn8	Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo}/Gt(ROSA)26Sor⁺ Polr1a^{tm1a(EUCOMM)Hmgu}/Polr1a^{tm1c(EUCOMM)Hmgu} Tg(Wnt1-cre/Esr1*)10Rth/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6N	MGI:7526475
cn9	Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo}/Gt(ROSA)26Sor⁺ Polr1a^{tm1d(EUCOMM)Hmgu}/Polr1a^{tm1c(EUCOMM)Hmgu} Tg(Wnt1-cre/Esr1*)10Rth/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6N	MGI:7526477
cn10	Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo}/Gt(ROSA)26Sor⁺ Polr1a^{tm1c(EUCOMM)Hmgu}/Polr1a^{tm1c(EUCOMM)Hmgu} Tg(Wnt1-cre/Esr1*)10Rth/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6N	MGI:7526481
cn11	Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo}/Gt(ROSA)26Sor⁺ Polr1a^{tm1d(EUCOMM)Hmgu}/Polr1a^{tm1c(EUCOMM)Hmgu} Tg(Mef2c-cre)2Blk/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6N	MGI:7526462
cn12	Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo}/Gt(ROSA)26Sor⁺ Polr1a^{tm1c(EUCOMM)Hmgu}/Polr1a^{tm1c(EUCOMM)Hmgu} Tg(Mef2c-cre)2Blk/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6N	MGI:7526463
cn13	Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo}/Gt(ROSA)26Sor⁺ Polr1a^{tm1a(EUCOMM)Hmgu}/Polr1a^{tm1c(EUCOMM)Hmgu} Tg(Sox10-cre)1Wdr/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6N * CBA	MGI:7526465
cn14	Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo}/Gt(ROSA)26Sor⁺ Polr1a^{tm1d(EUCOMM)Hmgu}/Polr1a^{tm1c(EUCOMM)Hmgu} Tg(Sox10-cre)1Wdr/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6N * CBA	MGI:7526466
cn15	Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo}/Gt(ROSA)26Sor⁺ Polr1a^{tm1c(EUCOMM)Hmgu}/Polr1a^{tm1c(EUCOMM)Hmgu} Tg(Sox10-cre)1Wdr/0	Not Specified	MGI:7526467

Allelic Composition	Foxg1^{tm1.1(cre)Ddmo}/0 Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo}/Gt(ROSA)26Sor⁺ Polr1a^em1Knwea/Polr1a^{tm1c(EUCOMM)Hmgu}
Genetic Background	involves: 129S1/Sv * 129T/Sv * 129X1/SvJ * C57BL/6N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxg1^{tm1.1(cre)Ddmo} mutation (1 available); any Foxg1 mutation (28 available)
Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo} mutation (10 available); any Gt(ROSA)26Sor mutation (944 available)
Polr1a^em1Knwea mutation (0 available); any Polr1a mutation (93 available)
Polr1a^{tm1c(EUCOMM)Hmgu} mutation (0 available); any Polr1a mutation (93 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

telencephalon hypoplasia ( J:335489 )

• in E14 and E17 embryos

• normal in E12 embryos

Allelic Composition	Foxg1^{tm1.1(cre)Ddmo}/Foxg1⁺ Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo}/Gt(ROSA)26Sor⁺ Polr1a^{tm1c(EUCOMM)Hmgu}/Polr1a^{tm1c(EUCOMM)Hmgu}
Genetic Background	involves: 129S1/Sv * 129T/Sv * 129X1/SvJ * C57BL/6N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxg1^{tm1.1(cre)Ddmo} mutation (1 available); any Foxg1 mutation (28 available)
Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo} mutation (10 available); any Gt(ROSA)26Sor mutation (944 available)
Polr1a^{tm1c(EUCOMM)Hmgu} mutation (0 available); any Polr1a mutation (93 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

telencephalon hypoplasia ( J:335489 )

• in E12, E14 and E17 embryos

Allelic Composition	Foxg1^{tm1.1(cre)Ddmo}/Foxg1⁺ Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo}/Gt(ROSA)26Sor⁺ Polr1a^{tm1d(EUCOMM)Hmgu}/Polr1a^{tm1c(EUCOMM)Hmgu}
Genetic Background	involves: 129S1/Sv * 129T/Sv * 129X1/SvJ * C57BL/6N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxg1^{tm1.1(cre)Ddmo} mutation (1 available); any Foxg1 mutation (28 available)
Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo} mutation (10 available); any Gt(ROSA)26Sor mutation (944 available)
Polr1a^{tm1c(EUCOMM)Hmgu} mutation (0 available); any Polr1a mutation (93 available)
Polr1a^{tm1d(EUCOMM)Hmgu} mutation (0 available); any Polr1a mutation (93 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

telencephalon hypoplasia ( J:335489 )

• in E12, E14 and E17 embryos

Allelic Composition	Foxg1^{tm1.1(cre)Ddmo}/Foxg1⁺ Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo}/Gt(ROSA)26Sor⁺ Polr1a^{tm1a(EUCOMM)Hmgu}/Polr1a^{tm1c(EUCOMM)Hmgu}
Genetic Background	involves: 129S1/Sv * 129T/Sv * 129X1/SvJ * C57BL/6N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxg1^{tm1.1(cre)Ddmo} mutation (1 available); any Foxg1 mutation (28 available)
Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo} mutation (10 available); any Gt(ROSA)26Sor mutation (944 available)
Polr1a^{tm1a(EUCOMM)Hmgu} mutation (1 available); any Polr1a mutation (93 available)
Polr1a^{tm1c(EUCOMM)Hmgu} mutation (0 available); any Polr1a mutation (93 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

telencephalon hypoplasia ( J:335489 )

• in E12, E14 and E17 embryos

Allelic Composition	Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo}/Gt(ROSA)26Sor⁺ Polr1a^em1Knwea/Polr1a^{tm1c(EUCOMM)Hmgu} Tg(Wnt1-cre/Esr1*)10Rth/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo} mutation (10 available); any Gt(ROSA)26Sor mutation (944 available)
Polr1a^em1Knwea mutation (0 available); any Polr1a mutation (93 available)
Polr1a^{tm1c(EUCOMM)Hmgu} mutation (0 available); any Polr1a mutation (93 available)
Tg(Wnt1-cre/Esr1*)10Rth mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

lethality throughout fetal growth and development ( J:335489 )

craniofacial

flat forehead ( J:335489 )

• starting in E9.5 embryos, worsening with age

facial cleft ( J:335489 )

growth/size/body

flat forehead ( J:335489 )

• starting in E9.5 embryos, worsening with age

facial cleft ( J:335489 )

cardiovascular system

cardiovascular system phenotype ( J:335489 )

N	• normal outflow tract septation in E12 embryos

Allelic Composition	Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo}/Gt(ROSA)26Sor⁺ Polr1a^em1Knwea/Polr1a^{tm1c(EUCOMM)Hmgu} Tg(Sox10-cre)1Wdr/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6N * CBA

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

craniofacial

midline cleft upper lip ( J:335489 )

• median lip notches in some E14-E15 embryos

cleft palate ( J:335489 )

• in some E14-E15 embryos

facial cleft ( J:335489 )

• in some E14-E15 embryos

digestive/alimentary system

cleft palate ( J:335489 )

• in some E14-E15 embryos

growth/size/body

midline cleft upper lip ( J:335489 )

• median lip notches in some E14-E15 embryos

cleft palate ( J:335489 )

• in some E14-E15 embryos

facial cleft ( J:335489 )

• in some E14-E15 embryos

Allelic Composition	Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo}/Gt(ROSA)26Sor⁺ Polr1a^{tm1a(EUCOMM)Hmgu}/Polr1a^{tm1c(EUCOMM)Hmgu} Tg(Mef2c-cre)2Blk/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo} mutation (10 available); any Gt(ROSA)26Sor mutation (944 available)
Polr1a^{tm1a(EUCOMM)Hmgu} mutation (1 available); any Polr1a mutation (93 available)
Polr1a^{tm1c(EUCOMM)Hmgu} mutation (0 available); any Polr1a mutation (93 available)
Tg(Mef2c-cre)2Blk mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

ventricular septal defect ( J:335489 )

• in E12 embryos

enlarged heart ( J:335489 )

• in newborns, owing to blood pooling

heart right ventricle hypoplasia ( J:335489 )

• in E12 embryos

abnormal heart right ventricle outflow tract morphology ( J:335489 )

• shorter in E10 embryos

absent heart right ventricle ( J:335489 )

• newborn hearts have only single ventricle

growth/size/body

enlarged heart ( J:335489 )

• in newborns, owing to blood pooling

Allelic Composition	Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo}/Gt(ROSA)26Sor⁺ Polr1a^{tm1a(EUCOMM)Hmgu}/Polr1a^{tm1c(EUCOMM)Hmgu} Tg(Wnt1-cre/Esr1*)10Rth/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo} mutation (10 available); any Gt(ROSA)26Sor mutation (944 available)
Polr1a^{tm1a(EUCOMM)Hmgu} mutation (1 available); any Polr1a mutation (93 available)
Polr1a^{tm1c(EUCOMM)Hmgu} mutation (0 available); any Polr1a mutation (93 available)
Tg(Wnt1-cre/Esr1*)10Rth mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

pharyngeal arch artery hypoplasia ( J:335489 )

• in E11.5 embryos

persistent truncus arteriosus ( J:335489 )

• in E12 embryos

decreased heart left ventricle wall thickness ( J:335489 )

• in E12.5 embryos

increased vascular permeability ( J:335489 )

• diffuse vascular leakage in E11.5 embryos

craniofacial

pharyngeal arch artery hypoplasia ( J:335489 )

• in E11.5 embryos

flat forehead ( J:335489 )

• starting in E9.5 embryos, worsening with age

embryo

pharyngeal arch artery hypoplasia ( J:335489 )

• in E11.5 embryos

growth/size/body

flat forehead ( J:335489 )

• starting in E9.5 embryos, worsening with age

mortality/aging

lethality throughout fetal growth and development ( J:335489 )

embryonic lethality during organogenesis, complete penetrance ( J:335489 )

Allelic Composition	Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo}/Gt(ROSA)26Sor⁺ Polr1a^{tm1d(EUCOMM)Hmgu}/Polr1a^{tm1c(EUCOMM)Hmgu} Tg(Wnt1-cre/Esr1*)10Rth/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo} mutation (10 available); any Gt(ROSA)26Sor mutation (944 available)
Polr1a^{tm1c(EUCOMM)Hmgu} mutation (0 available); any Polr1a mutation (93 available)
Polr1a^{tm1d(EUCOMM)Hmgu} mutation (0 available); any Polr1a mutation (93 available)
Tg(Wnt1-cre/Esr1*)10Rth mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

pharyngeal arch artery hypoplasia ( J:335489 )

• in E11.5 embryos

persistent truncus arteriosus ( J:335489 )

• in E12 embryos

decreased heart left ventricle wall thickness ( J:335489 )

• in E12.5 embryos

increased vascular permeability ( J:335489 )

• diffuse vascular leakage in E11.5 embryos

craniofacial

pharyngeal arch artery hypoplasia ( J:335489 )

• in E11.5 embryos

flat forehead ( J:335489 )

• starting in E9.5 embryos, worsening with age

embryo

pharyngeal arch artery hypoplasia ( J:335489 )

• in E11.5 embryos

growth/size/body

flat forehead ( J:335489 )

• starting in E9.5 embryos, worsening with age

mortality/aging

lethality throughout fetal growth and development ( J:335489 )

embryonic lethality during organogenesis, complete penetrance ( J:335489 )

Allelic Composition	Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo}/Gt(ROSA)26Sor⁺ Polr1a^{tm1c(EUCOMM)Hmgu}/Polr1a^{tm1c(EUCOMM)Hmgu} Tg(Wnt1-cre/Esr1*)10Rth/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo} mutation (10 available); any Gt(ROSA)26Sor mutation (944 available)
Polr1a^{tm1c(EUCOMM)Hmgu} mutation (0 available); any Polr1a mutation (93 available)
Tg(Wnt1-cre/Esr1*)10Rth mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

pharyngeal arch artery hypoplasia ( J:335489 )

• in E11.5 embryos

persistent truncus arteriosus ( J:335489 )

• in E12 embryos

decreased heart left ventricle wall thickness ( J:335489 )

• in E12.5 embryos

increased vascular permeability ( J:335489 )

• diffuse vascular leakage in E11.5 embryos

craniofacial

pharyngeal arch artery hypoplasia ( J:335489 )

• in E11.5 embryos

flat forehead ( J:335489 )

• starting in E9.5 embryos, worsening with age

embryo

pharyngeal arch artery hypoplasia ( J:335489 )

• in E11.5 embryos

growth/size/body

flat forehead ( J:335489 )

• starting in E9.5 embryos, worsening with age

mortality/aging

lethality throughout fetal growth and development ( J:335489 )

embryonic lethality during organogenesis, complete penetrance ( J:335489 )

Allelic Composition	Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo}/Gt(ROSA)26Sor⁺ Polr1a^{tm1d(EUCOMM)Hmgu}/Polr1a^{tm1c(EUCOMM)Hmgu} Tg(Mef2c-cre)2Blk/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo} mutation (10 available); any Gt(ROSA)26Sor mutation (944 available)
Polr1a^{tm1c(EUCOMM)Hmgu} mutation (0 available); any Polr1a mutation (93 available)
Polr1a^{tm1d(EUCOMM)Hmgu} mutation (0 available); any Polr1a mutation (93 available)
Tg(Mef2c-cre)2Blk mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

ventricular septal defect ( J:335489 )

• in E12 embryos

enlarged heart ( J:335489 )

• in newborns, owing to blood pooling

heart right ventricle hypoplasia ( J:335489 )

• in E12 embryos

abnormal heart right ventricle outflow tract morphology ( J:335489 )

• shorter in E10 embryos

absent heart right ventricle ( J:335489 )

• newborn hearts have only single ventricle

growth/size/body

enlarged heart ( J:335489 )

• in newborns, owing to blood pooling

Allelic Composition	Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo}/Gt(ROSA)26Sor⁺ Polr1a^{tm1c(EUCOMM)Hmgu}/Polr1a^{tm1c(EUCOMM)Hmgu} Tg(Mef2c-cre)2Blk/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo} mutation (10 available); any Gt(ROSA)26Sor mutation (944 available)
Polr1a^{tm1c(EUCOMM)Hmgu} mutation (0 available); any Polr1a mutation (93 available)
Tg(Mef2c-cre)2Blk mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

ventricular septal defect ( J:335489 )

• in E12 embryos

enlarged heart ( J:335489 )

• in newborns, owing to blood pooling

heart right ventricle hypoplasia ( J:335489 )

• in E12 embryos

abnormal heart right ventricle outflow tract morphology ( J:335489 )

• shorter in E10 embryos

absent heart right ventricle ( J:335489 )

• newborn hearts have only single ventricle

growth/size/body

enlarged heart ( J:335489 )

• in newborns, owing to blood pooling

Allelic Composition	Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo}/Gt(ROSA)26Sor⁺ Polr1a^{tm1a(EUCOMM)Hmgu}/Polr1a^{tm1c(EUCOMM)Hmgu} Tg(Sox10-cre)1Wdr/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6N * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo} mutation (10 available); any Gt(ROSA)26Sor mutation (944 available)
Polr1a^{tm1a(EUCOMM)Hmgu} mutation (1 available); any Polr1a mutation (93 available)
Polr1a^{tm1c(EUCOMM)Hmgu} mutation (0 available); any Polr1a mutation (93 available)
Tg(Sox10-cre)1Wdr mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:335489 )

N	• normal outflow tract septation in E9.5 embryos

craniofacial

frontal bone hypoplasia ( J:335489 )

• in E16 and E17 embryos

temporal bone squamous part hypoplasia ( J:335489 )

• in E16 and E17 embryos

cleft chin ( J:335489 )

• mandibular cleft in E14-E17 embryos

short mandible ( J:335489 )

• in E17 embryos

nasal bone hypoplasia ( J:335489 )

• in E16 and E17 embryos

cleft palate ( J:335489 )

• in E16 and E17 embryos

facial cleft ( J:335489 )

• in E16 and E17 embryos

digestive/alimentary system

cleft palate ( J:335489 )

• in E16 and E17 embryos

growth/size/body

cleft chin ( J:335489 )

• mandibular cleft in E14-E17 embryos

nasal bone hypoplasia ( J:335489 )

• in E16 and E17 embryos

cleft palate ( J:335489 )

• in E16 and E17 embryos

facial cleft ( J:335489 )

• in E16 and E17 embryos

respiratory system

nasal bone hypoplasia ( J:335489 )

• in E16 and E17 embryos

skeleton

frontal bone hypoplasia ( J:335489 )

• in E16 and E17 embryos

temporal bone squamous part hypoplasia ( J:335489 )

• in E16 and E17 embryos

cleft chin ( J:335489 )

• mandibular cleft in E14-E17 embryos

short mandible ( J:335489 )

• in E17 embryos

nasal bone hypoplasia ( J:335489 )

• in E16 and E17 embryos

Allelic Composition	Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo}/Gt(ROSA)26Sor⁺ Polr1a^{tm1d(EUCOMM)Hmgu}/Polr1a^{tm1c(EUCOMM)Hmgu} Tg(Sox10-cre)1Wdr/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6N * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo} mutation (10 available); any Gt(ROSA)26Sor mutation (944 available)
Polr1a^{tm1c(EUCOMM)Hmgu} mutation (0 available); any Polr1a mutation (93 available)
Polr1a^{tm1d(EUCOMM)Hmgu} mutation (0 available); any Polr1a mutation (93 available)
Tg(Sox10-cre)1Wdr mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:335489 )

• normal outflow tract septation in E9.5 embryos

craniofacial

frontal bone hypoplasia ( J:335489 )

• in E16 and E17 embryos

temporal bone squamous part hypoplasia ( J:335489 )

• in E16 and E17 embryos

cleft chin ( J:335489 )

• mandibular cleft in E14-E17 embryos

short mandible ( J:335489 )

• in E17 embryos

nasal bone hypoplasia ( J:335489 )

• in E16 and E17 embryos

cleft palate ( J:335489 )

• in E16 and E17 embryos

facial cleft ( J:335489 )

• in E16 and E17 embryos

digestive/alimentary system

cleft palate ( J:335489 )

• in E16 and E17 embryos

growth/size/body

cleft chin ( J:335489 )

• mandibular cleft in E14-E17 embryos

nasal bone hypoplasia ( J:335489 )

• in E16 and E17 embryos

cleft palate ( J:335489 )

• in E16 and E17 embryos

facial cleft ( J:335489 )

• in E16 and E17 embryos

respiratory system

nasal bone hypoplasia ( J:335489 )

• in E16 and E17 embryos

skeleton

frontal bone hypoplasia ( J:335489 )

• in E16 and E17 embryos

temporal bone squamous part hypoplasia ( J:335489 )

• in E16 and E17 embryos

cleft chin ( J:335489 )

• mandibular cleft in E14-E17 embryos

short mandible ( J:335489 )

• in E17 embryos

nasal bone hypoplasia ( J:335489 )

• in E16 and E17 embryos

Allelic Composition	Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo}/Gt(ROSA)26Sor⁺ Polr1a^{tm1c(EUCOMM)Hmgu}/Polr1a^{tm1c(EUCOMM)Hmgu} Tg(Sox10-cre)1Wdr/0
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo} mutation (10 available); any Gt(ROSA)26Sor mutation (944 available)
Polr1a^{tm1c(EUCOMM)Hmgu} mutation (0 available); any Polr1a mutation (93 available)
Tg(Sox10-cre)1Wdr mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:335489 )

• normal outflow tract septation in E9.5 embryos

craniofacial

frontal bone hypoplasia ( J:335489 )

• in E16 and E17 embryos

temporal bone squamous part hypoplasia ( J:335489 )

• in E16 and E17 embryos

cleft chin ( J:335489 )

• mandibular cleft in E14-E17 embryos

short mandible ( J:335489 )

• in E17 embryos

nasal bone hypoplasia ( J:335489 )

• in E16 and E17 embryos

cleft palate ( J:335489 )

• in E16 and E17 embryos

facial cleft ( J:335489 )

• in E16 and E17 embryos

digestive/alimentary system

cleft palate ( J:335489 )

• in E16 and E17 embryos

growth/size/body

cleft chin ( J:335489 )

• mandibular cleft in E14-E17 embryos

nasal bone hypoplasia ( J:335489 )

• in E16 and E17 embryos

cleft palate ( J:335489 )

• in E16 and E17 embryos

facial cleft ( J:335489 )

• in E16 and E17 embryos

respiratory system

nasal bone hypoplasia ( J:335489 )

• in E16 and E17 embryos

skeleton

frontal bone hypoplasia ( J:335489 )

• in E16 and E17 embryos

temporal bone squamous part hypoplasia ( J:335489 )

• in E16 and E17 embryos

cleft chin ( J:335489 )

• mandibular cleft in E14-E17 embryos

short mandible ( J:335489 )

• in E17 embryos

nasal bone hypoplasia ( J:335489 )

• in E16 and E17 embryos

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/30/2024 MGI 6.23