Phenotypes associated with this allele

• Allele Symbol: Polr1a^{tm1c(EUCOMM)Hmgu}
• Allele Name: targeted mutation 1c, Helmholtz Zentrum Muenchen GmbH
• Allele ID: MGI:7432631
• Summary: 15 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Foxg1^tm1.1(cre)Ddmo/0 Gt(ROSA)26Sor^tm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sor^+ Polr1a^em1Knwea/Polr1a^tm1c(EUCOMM)Hmgu	involves: 129S1/Sv * 129T/Sv * 129X1/SvJ * C57BL/6N	MGI:7526484
cn2	Foxg1^tm1.1(cre)Ddmo/Foxg1^+ Gt(ROSA)26Sor^tm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sor^+ Polr1a^tm1d(EUCOMM)Hmgu/Polr1a^tm1c(EUCOMM)Hmgu	involves: 129S1/Sv * 129T/Sv * 129X1/SvJ * C57BL/6N	MGI:7526488
cn3	Foxg1^tm1.1(cre)Ddmo/Foxg1^+ Gt(ROSA)26Sor^tm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sor^+ Polr1a^tm1a(EUCOMM)Hmgu/Polr1a^tm1c(EUCOMM)Hmgu	involves: 129S1/Sv * 129T/Sv * 129X1/SvJ * C57BL/6N	MGI:7526487
cn4	Foxg1^tm1.1(cre)Ddmo/Foxg1^+ Gt(ROSA)26Sor^tm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sor^+ Polr1a^tm1c(EUCOMM)Hmgu/Polr1a^tm1c(EUCOMM)Hmgu	involves: 129S1/Sv * 129T/Sv * 129X1/SvJ * C57BL/6N	MGI:7526489
cn5	Gt(ROSA)26Sor^tm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sor^+ Polr1a^em1Knwea/Polr1a^tm1c(EUCOMM)Hmgu Tg(Wnt1-cre/Esr1*)10Rth/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6N	MGI:7526471
cn6	Gt(ROSA)26Sor^tm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sor^+ Polr1a^em1Knwea/Polr1a^tm1c(EUCOMM)Hmgu Tg(Sox10-cre)1Wdr/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6N * CBA	MGI:7526470
cn7	Gt(ROSA)26Sor^tm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sor^+ Polr1a^tm1a(EUCOMM)Hmgu/Polr1a^tm1c(EUCOMM)Hmgu Tg(Wnt1-cre/Esr1*)10Rth/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6N	MGI:7526475
cn8	Gt(ROSA)26Sor^tm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sor^+ Polr1a^tm1d(EUCOMM)Hmgu/Polr1a^tm1c(EUCOMM)Hmgu Tg(Mef2c-cre)2Blk/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6N	MGI:7526462
cn9	Gt(ROSA)26Sor^tm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sor^+ Polr1a^tm1c(EUCOMM)Hmgu/Polr1a^tm1c(EUCOMM)Hmgu Tg(Mef2c-cre)2Blk/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6N	MGI:7526463
cn10	Gt(ROSA)26Sor^tm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sor^+ Polr1a^tm1a(EUCOMM)Hmgu/Polr1a^tm1c(EUCOMM)Hmgu Tg(Mef2c-cre)2Blk/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6N	MGI:7526459
cn11	Gt(ROSA)26Sor^tm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sor^+ Polr1a^tm1d(EUCOMM)Hmgu/Polr1a^tm1c(EUCOMM)Hmgu Tg(Wnt1-cre/Esr1*)10Rth/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6N	MGI:7526477
cn12	Gt(ROSA)26Sor^tm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sor^+ Polr1a^tm1c(EUCOMM)Hmgu/Polr1a^tm1c(EUCOMM)Hmgu Tg(Wnt1-cre/Esr1*)10Rth/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6N	MGI:7526481
cn13	Gt(ROSA)26Sor^tm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sor^+ Polr1a^tm1d(EUCOMM)Hmgu/Polr1a^tm1c(EUCOMM)Hmgu Tg(Sox10-cre)1Wdr/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6N * CBA	MGI:7526466
cn14	Gt(ROSA)26Sor^tm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sor^+ Polr1a^tm1a(EUCOMM)Hmgu/Polr1a^tm1c(EUCOMM)Hmgu Tg(Sox10-cre)1Wdr/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6N * CBA	MGI:7526465
cn15	Gt(ROSA)26Sor^tm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sor^+ Polr1a^tm1c(EUCOMM)Hmgu/Polr1a^tm1c(EUCOMM)Hmgu Tg(Sox10-cre)1Wdr/0	Not Specified	MGI:7526467

Genotype
MGI:7526484

cn1

• Allelic Composition: Foxg1^{tm1.1(cre)Ddmo}/0; Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo}/Gt(ROSA)26Sor⁺; Polr1a^em1Knwea/Polr1a^{tm1c(EUCOMM)Hmgu}
• Genetic Background: involves: 129S1/Sv * 129T/Sv * 129X1/SvJ * C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

telencephalon hypoplasia ( J:335489 )

• in E14 and E17 embryos

• normal in E12 embryos

Genotype
MGI:7526488

cn2

• Allelic Composition: Foxg1^{tm1.1(cre)Ddmo}/Foxg1⁺; Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo}/Gt(ROSA)26Sor⁺; Polr1a^{tm1d(EUCOMM)Hmgu}/Polr1a^{tm1c(EUCOMM)Hmgu}
• Genetic Background: involves: 129S1/Sv * 129T/Sv * 129X1/SvJ * C57BL/6N

nervous system

telencephalon hypoplasia ( J:335489 )

• in E12, E14 and E17 embryos

Genotype
MGI:7526487

cn3

• Allelic Composition: Foxg1^{tm1.1(cre)Ddmo}/Foxg1⁺; Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo}/Gt(ROSA)26Sor⁺; Polr1a^{tm1a(EUCOMM)Hmgu}/Polr1a^{tm1c(EUCOMM)Hmgu}
• Genetic Background: involves: 129S1/Sv * 129T/Sv * 129X1/SvJ * C57BL/6N

nervous system

telencephalon hypoplasia ( J:335489 )

• in E12, E14 and E17 embryos

Genotype
MGI:7526489

cn4

• Allelic Composition: Foxg1^{tm1.1(cre)Ddmo}/Foxg1⁺; Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo}/Gt(ROSA)26Sor⁺; Polr1a^{tm1c(EUCOMM)Hmgu}/Polr1a^{tm1c(EUCOMM)Hmgu}
• Genetic Background: involves: 129S1/Sv * 129T/Sv * 129X1/SvJ * C57BL/6N

nervous system

telencephalon hypoplasia ( J:335489 )

• in E12, E14 and E17 embryos

Genotype
MGI:7526471

cn5

• Allelic Composition: Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo}/Gt(ROSA)26Sor⁺; Polr1a^em1Knwea/Polr1a^{tm1c(EUCOMM)Hmgu}; Tg(Wnt1-cre/Esr1*)10Rth/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6N

mortality/aging

lethality throughout fetal growth and development ( J:335489 )

craniofacial

flat forehead ( J:335489 )

• starting in E9.5 embryos, worsening with age

facial cleft ( J:335489 )

growth/size/body

flat forehead ( J:335489 )

• starting in E9.5 embryos, worsening with age

facial cleft ( J:335489 )

cardiovascular system

cardiovascular system phenotype ( J:335489 )

N • normal outflow tract septation in E12 embryos

Genotype
MGI:7526470

cn6

• Allelic Composition: Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo}/Gt(ROSA)26Sor⁺; Polr1a^em1Knwea/Polr1a^{tm1c(EUCOMM)Hmgu}; Tg(Sox10-cre)1Wdr/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6N * CBA

craniofacial

midline cleft upper lip ( J:335489 )

• median lip notches in some E14-E15 embryos

cleft palate ( J:335489 )

• in some E14-E15 embryos

facial cleft ( J:335489 )

• in some E14-E15 embryos

digestive/alimentary system

cleft palate ( J:335489 )

• in some E14-E15 embryos

growth/size/body

midline cleft upper lip ( J:335489 )

• median lip notches in some E14-E15 embryos

cleft palate ( J:335489 )

• in some E14-E15 embryos

facial cleft ( J:335489 )

• in some E14-E15 embryos

Genotype
MGI:7526475

cn7

• Allelic Composition: Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo}/Gt(ROSA)26Sor⁺; Polr1a^{tm1a(EUCOMM)Hmgu}/Polr1a^{tm1c(EUCOMM)Hmgu}; Tg(Wnt1-cre/Esr1*)10Rth/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6N

cardiovascular system

pharyngeal arch artery hypoplasia ( J:335489 )

• in E11.5 embryos

persistent truncus arteriosus ( J:335489 )

• in E12 embryos

decreased heart left ventricle wall thickness ( J:335489 )

• in E12.5 embryos

increased vascular permeability ( J:335489 )

• diffuse vascular leakage in E11.5 embryos

craniofacial

pharyngeal arch artery hypoplasia ( J:335489 )

• in E11.5 embryos

flat forehead ( J:335489 )

• starting in E9.5 embryos, worsening with age

embryo

pharyngeal arch artery hypoplasia ( J:335489 )

• in E11.5 embryos

growth/size/body

flat forehead ( J:335489 )

• starting in E9.5 embryos, worsening with age

mortality/aging

lethality throughout fetal growth and development ( J:335489 )

embryonic lethality during organogenesis, complete penetrance ( J:335489 )

Genotype
MGI:7526462

cn8

• Allelic Composition: Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo}/Gt(ROSA)26Sor⁺; Polr1a^{tm1d(EUCOMM)Hmgu}/Polr1a^{tm1c(EUCOMM)Hmgu}; Tg(Mef2c-cre)2Blk/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6N

cardiovascular system

ventricular septal defect ( J:335489 )

• in E12 embryos

enlarged heart ( J:335489 )

• in newborns, owing to blood pooling

heart right ventricle hypoplasia ( J:335489 )

• in E12 embryos

abnormal heart right ventricle outflow tract morphology ( J:335489 )

• shorter in E10 embryos

absent heart right ventricle ( J:335489 )

• newborn hearts have only single ventricle

growth/size/body

enlarged heart ( J:335489 )

• in newborns, owing to blood pooling

Genotype
MGI:7526463

cn9

• Allelic Composition: Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo}/Gt(ROSA)26Sor⁺; Polr1a^{tm1c(EUCOMM)Hmgu}/Polr1a^{tm1c(EUCOMM)Hmgu}; Tg(Mef2c-cre)2Blk/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6N

cardiovascular system

ventricular septal defect ( J:335489 )

• in E12 embryos

enlarged heart ( J:335489 )

• in newborns, owing to blood pooling

heart right ventricle hypoplasia ( J:335489 )

• in E12 embryos

abnormal heart right ventricle outflow tract morphology ( J:335489 )

• shorter in E10 embryos

absent heart right ventricle ( J:335489 )

• newborn hearts have only single ventricle

growth/size/body

enlarged heart ( J:335489 )

• in newborns, owing to blood pooling

Genotype
MGI:7526459

cn10

• Allelic Composition: Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo}/Gt(ROSA)26Sor⁺; Polr1a^{tm1a(EUCOMM)Hmgu}/Polr1a^{tm1c(EUCOMM)Hmgu}; Tg(Mef2c-cre)2Blk/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6N

cardiovascular system

ventricular septal defect ( J:335489 )

• in E12 embryos

enlarged heart ( J:335489 )

• in newborns, owing to blood pooling

heart right ventricle hypoplasia ( J:335489 )

• in E12 embryos

abnormal heart right ventricle outflow tract morphology ( J:335489 )

• shorter in E10 embryos

absent heart right ventricle ( J:335489 )

• newborn hearts have only single ventricle

growth/size/body

enlarged heart ( J:335489 )

• in newborns, owing to blood pooling

Genotype
MGI:7526477

cn11

• Allelic Composition: Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo}/Gt(ROSA)26Sor⁺; Polr1a^{tm1d(EUCOMM)Hmgu}/Polr1a^{tm1c(EUCOMM)Hmgu}; Tg(Wnt1-cre/Esr1*)10Rth/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6N

cardiovascular system

pharyngeal arch artery hypoplasia ( J:335489 )

• in E11.5 embryos

persistent truncus arteriosus ( J:335489 )

• in E12 embryos

decreased heart left ventricle wall thickness ( J:335489 )

• in E12.5 embryos

increased vascular permeability ( J:335489 )

• diffuse vascular leakage in E11.5 embryos

craniofacial

pharyngeal arch artery hypoplasia ( J:335489 )

• in E11.5 embryos

flat forehead ( J:335489 )

• starting in E9.5 embryos, worsening with age

embryo

pharyngeal arch artery hypoplasia ( J:335489 )

• in E11.5 embryos

growth/size/body

flat forehead ( J:335489 )

• starting in E9.5 embryos, worsening with age

mortality/aging

lethality throughout fetal growth and development ( J:335489 )

embryonic lethality during organogenesis, complete penetrance ( J:335489 )

Genotype
MGI:7526481

cn12

• Allelic Composition: Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo}/Gt(ROSA)26Sor⁺; Polr1a^{tm1c(EUCOMM)Hmgu}/Polr1a^{tm1c(EUCOMM)Hmgu}; Tg(Wnt1-cre/Esr1*)10Rth/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6N

cardiovascular system

pharyngeal arch artery hypoplasia ( J:335489 )

• in E11.5 embryos

persistent truncus arteriosus ( J:335489 )

• in E12 embryos

decreased heart left ventricle wall thickness ( J:335489 )

• in E12.5 embryos

increased vascular permeability ( J:335489 )

• diffuse vascular leakage in E11.5 embryos

craniofacial

pharyngeal arch artery hypoplasia ( J:335489 )

• in E11.5 embryos

flat forehead ( J:335489 )

• starting in E9.5 embryos, worsening with age

embryo

pharyngeal arch artery hypoplasia ( J:335489 )

• in E11.5 embryos

growth/size/body

flat forehead ( J:335489 )

• starting in E9.5 embryos, worsening with age

mortality/aging

lethality throughout fetal growth and development ( J:335489 )

embryonic lethality during organogenesis, complete penetrance ( J:335489 )

Genotype
MGI:7526466

cn13

• Allelic Composition: Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo}/Gt(ROSA)26Sor⁺; Polr1a^{tm1d(EUCOMM)Hmgu}/Polr1a^{tm1c(EUCOMM)Hmgu}; Tg(Sox10-cre)1Wdr/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6N * CBA

cardiovascular system

cardiovascular system phenotype ( J:335489 )

• normal outflow tract septation in E9.5 embryos

craniofacial

frontal bone hypoplasia ( J:335489 )

• in E16 and E17 embryos

temporal bone squamous part hypoplasia ( J:335489 )

• in E16 and E17 embryos

cleft chin ( J:335489 )

• mandibular cleft in E14-E17 embryos

short mandible ( J:335489 )

• in E17 embryos

nasal bone hypoplasia ( J:335489 )

• in E16 and E17 embryos

cleft palate ( J:335489 )

• in E16 and E17 embryos

facial cleft ( J:335489 )

• in E16 and E17 embryos

digestive/alimentary system

cleft palate ( J:335489 )

• in E16 and E17 embryos

growth/size/body

frontal bone hypoplasia ( J:335489 )

• in E16 and E17 embryos

cleft chin ( J:335489 )

• mandibular cleft in E14-E17 embryos

short mandible ( J:335489 )

• in E17 embryos

nasal bone hypoplasia ( J:335489 )

• in E16 and E17 embryos

cleft palate ( J:335489 )

• in E16 and E17 embryos

facial cleft ( J:335489 )

• in E16 and E17 embryos

respiratory system

nasal bone hypoplasia ( J:335489 )

• in E16 and E17 embryos

skeleton

frontal bone hypoplasia ( J:335489 )

• in E16 and E17 embryos

temporal bone squamous part hypoplasia ( J:335489 )

• in E16 and E17 embryos

cleft chin ( J:335489 )

• mandibular cleft in E14-E17 embryos

short mandible ( J:335489 )

• in E17 embryos

nasal bone hypoplasia ( J:335489 )

• in E16 and E17 embryos

Genotype
MGI:7526465

cn14

• Allelic Composition: Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo}/Gt(ROSA)26Sor⁺; Polr1a^{tm1a(EUCOMM)Hmgu}/Polr1a^{tm1c(EUCOMM)Hmgu}; Tg(Sox10-cre)1Wdr/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6N * CBA

cardiovascular system

cardiovascular system phenotype ( J:335489 )

N • normal outflow tract septation in E9.5 embryos

craniofacial

frontal bone hypoplasia ( J:335489 )

• in E16 and E17 embryos

temporal bone squamous part hypoplasia ( J:335489 )

• in E16 and E17 embryos

cleft chin ( J:335489 )

• mandibular cleft in E14-E17 embryos

short mandible ( J:335489 )

• in E17 embryos

nasal bone hypoplasia ( J:335489 )

• in E16 and E17 embryos

cleft palate ( J:335489 )

• in E16 and E17 embryos

facial cleft ( J:335489 )

• in E16 and E17 embryos

digestive/alimentary system

cleft palate ( J:335489 )

• in E16 and E17 embryos

growth/size/body

frontal bone hypoplasia ( J:335489 )

• in E16 and E17 embryos

cleft chin ( J:335489 )

• mandibular cleft in E14-E17 embryos

short mandible ( J:335489 )

• in E17 embryos

nasal bone hypoplasia ( J:335489 )

• in E16 and E17 embryos

cleft palate ( J:335489 )

• in E16 and E17 embryos

facial cleft ( J:335489 )

• in E16 and E17 embryos

respiratory system

nasal bone hypoplasia ( J:335489 )

• in E16 and E17 embryos

skeleton

frontal bone hypoplasia ( J:335489 )

• in E16 and E17 embryos

temporal bone squamous part hypoplasia ( J:335489 )

• in E16 and E17 embryos

cleft chin ( J:335489 )

• mandibular cleft in E14-E17 embryos

short mandible ( J:335489 )

• in E17 embryos

nasal bone hypoplasia ( J:335489 )

• in E16 and E17 embryos

Genotype
MGI:7526467

cn15

• Allelic Composition: Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo}/Gt(ROSA)26Sor⁺; Polr1a^{tm1c(EUCOMM)Hmgu}/Polr1a^{tm1c(EUCOMM)Hmgu}; Tg(Sox10-cre)1Wdr/0
• Genetic Background: Not Specified

cardiovascular system

cardiovascular system phenotype ( J:335489 )

• normal outflow tract septation in E9.5 embryos

craniofacial

frontal bone hypoplasia ( J:335489 )

• in E16 and E17 embryos

temporal bone squamous part hypoplasia ( J:335489 )

• in E16 and E17 embryos

cleft chin ( J:335489 )

• mandibular cleft in E14-E17 embryos

short mandible ( J:335489 )

• in E17 embryos

nasal bone hypoplasia ( J:335489 )

• in E16 and E17 embryos

cleft palate ( J:335489 )

• in E16 and E17 embryos

facial cleft ( J:335489 )

• in E16 and E17 embryos

digestive/alimentary system

cleft palate ( J:335489 )

• in E16 and E17 embryos

growth/size/body

frontal bone hypoplasia ( J:335489 )

• in E16 and E17 embryos

cleft chin ( J:335489 )

• mandibular cleft in E14-E17 embryos

short mandible ( J:335489 )

• in E17 embryos

nasal bone hypoplasia ( J:335489 )

• in E16 and E17 embryos

cleft palate ( J:335489 )

• in E16 and E17 embryos

facial cleft ( J:335489 )

• in E16 and E17 embryos

respiratory system

nasal bone hypoplasia ( J:335489 )

• in E16 and E17 embryos

skeleton

frontal bone hypoplasia ( J:335489 )

• in E16 and E17 embryos

temporal bone squamous part hypoplasia ( J:335489 )

• in E16 and E17 embryos

cleft chin ( J:335489 )

• mandibular cleft in E14-E17 embryos

short mandible ( J:335489 )

• in E17 embryos

nasal bone hypoplasia ( J:335489 )

• in E16 and E17 embryos