Phenotypes associated with this allele

• Allele Symbol: Bex3^em1Jjcar
• Allele Name: endonuclease-mediated mutation 1, Jaime J Carvajal Garcia-Valdecasas
• Allele ID: MGI:7430934
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Bex3^em1Jjcar/Bex3^em1Jjcar	involves: C57BL/6 * CBA	MGI:7431243

Genotype
MGI:7431243

hm1

• Allelic Composition: Bex3^em1Jjcar/Bex3^em1Jjcar
• Genetic Background: involves: C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal brain interneuron morphology ( J:332746 )

• decreased density in motor, cingulate and sensory cortices, and caudate-putamen

abnormal brain ventricle morphology ( J:332746 )

• increased surface

dilated brain ventricle ( J:332746 )

• enlarged

abnormal hippocampus stratum radiatum morphology ( J:332746 )

• reduced total neuron density in the stratum radiatum of the CA1-12 hippocampal fields

abnormal cerebral cortex morphology ( J:332746 )

• reduced cortical surface and size

small cerebellum ( J:332746 )

decreased excitatory postsynaptic current frequency ( J:332746 )

• decreased total spontaneous activity frequency

abnormal inhibitory postsynaptic currents ( J:332746 )

• strongly reduced frequency

increased prepulse inhibition ( J:332746 )

behavior/neurological

behavior/neurological phenotype ( J:332746 )

• mice exhibit normal locomotor function

impaired passive avoidance behavior ( J:332746 )

abnormal long-term object recognition memory ( J:332746 )

• lower performance in object recognition memory

abnormal spatial working memory ( J:332746 )

• reduced spontaneous alternation in a Y-maze

abnormal response to social novelty ( J:332746 )

• reduced interaction with a novel mouse

increased grooming behavior ( J:332746 )

increased stereotypic behavior ( J:332746 )

abnormal nest building behavior ( J:332746 )

• impaired

craniofacial

enlarged frontal bone ( J:332746 )

• increased size of the posterior parameter measurement and enlarged bone cavity harboring the cerebellum

large orbits ( J:332746 )

• increased width with rounder eye appearance

skeleton

enlarged frontal bone ( J:332746 )

• increased size of the posterior parameter measurement and enlarged bone cavity harboring the cerebellum

large orbits ( J:332746 )

• increased width with rounder eye appearance

vision/eye

large orbits ( J:332746 )

• increased width with rounder eye appearance