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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ormdl2em1Pdra
endonuclease-mediated mutation 1, Petr Draber
MGI:7427586
Summary 2 genotypes


Genotype
MGI:7427595
hm1
Allelic
Composition		 Ormdl2em1Pdra/Ormdl2em1Pdra
Genetic
Background		 C57BL/6-Ormdl2em1Pdra
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ormdl2em1Pdra mutation (0 available); any Ormdl2 mutation (9 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:328837 )
N
• bone marrow-derived mast cells exhibit normal proliferation, degranulation, and ceramide and sphingosine levels
• mice exhibit normal response to passive cutaneous or systemic anaphylaxis




Genotype
MGI:7427599
cx2
Allelic
Composition		 Ormdl2em1Pdra/Ormdl2em1Pdra
Ormdl3em1Pdra/Ormdl3em1Pdra
Genetic
Background		 C57BL/6-Ormdl2em1Pdra Ormdl3em1Pdra
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ormdl2em1Pdra mutation (0 available); any Ormdl2 mutation (9 available)
Ormdl3em1Pdra mutation (0 available); any Ormdl3 mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal mast cell physiology ( J:328837 )
• bone marrow-derived mast cells exhibit increased proliferation compared with cells from wild-type mice
abnormal type I hypersensitivity reaction ( J:328837 )
• mice exhibit increased passive cutaneous anaphylaxis but faster recovery from passive systemic anaphylaxis compared with wild-type mice
• however, mice exhibit normal passive cutaneous anaphylaxis
increased interleukin-4 secretion ( J:328837 )
• in antigen-activated bone marrow-derived mast cells
increased interleukin-6 secretion ( J:328837 )
• in antigen-activated bone marrow-derived mast cells
increased tumor necrosis factor secretion ( J:328837 )
• in antigen-activated bone marrow-derived mast cells

homeostasis/metabolism
increased ceramide level ( J:328837 )
• in bone marrow-derived mast cells
increased sphingosine level ( J:328837 )
• in bone marrow-derived mast cells

hematopoietic system
abnormal mast cell physiology ( J:328837 )
• bone marrow-derived mast cells exhibit increased proliferation compared with cells from wild-type mice

cellular




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/14/2024
MGI 6.23 		The Jackson Laboratory